1630974-71-8

Basic information

• Product Name: 2-(p-tolyl)-4-nitro-2,3-dihydroisoindol-1-one
• Synonyms: 2-(p-tolyl)-4-nitro-2,3-dihydroisoindol-1-one
• CAS NO: 1630974-71-8
• Molecular Weight: 268.272
• Mol File: 1630974-71-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(p-tolyl)-4-nitro-2,3-dihydroisoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-tolyl)-4-nitro-2,3-dihydroisoindol-1-one(1630974-71-8)
• EPA Substance Registry System: 2-(p-tolyl)-4-nitro-2,3-dihydroisoindol-1-one(1630974-71-8)

Safety Data

• Hazardous Substances Data: 1630974-71-8(Hazardous Substances Data)

Upstream product

• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 106-49-0 p-toluidine 
• 98475-07-1 2-bromomethyl-3-nitro-benzoic acid methyl ester 

Downstream Products

• 1630974-78-5 benzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester 
• 1630974-79-6 2,2-dimethylpropionic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester 
• 1630974-80-9 4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester 
• 1630974-81-0 4-nitrobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester 
• 1630974-74-1 2-(p-tolyl)-3-hydroxy-4-nitro-2,3-dihydroisoindol-1-one 
• 1630974-77-4 acetic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester 

Relevant articles and documents

Synthesis of hydroxylactams and esters derived from thalidomide and their antitumor activities

A novel and convenient route for the synthesis of a series of thalidomide derivatives is described. Compound 2 was cyclized with different amines under alkaline condition to obtain 4-nitro substituted phthalimidines 3a-d. Hydroxylactams 4a-d were produced via bromination and hydroxylation. Different acyl chlorides were reacted with hydroxylactams to provide the desired esters 5a-d. All compounds were evaluated by MTT assay for their inhibitory activities against HCT-116, MG-63, MCF-7, HUVEC and HMVEC cell lines in vitro. Most of them showed no obvious cytotoxic effect on normal human cells, compounds 4a-d, 5a2, 5a4, 5a5, 5b2, 5c2 and 5d2 exhibited potent antitumor activities, among which compounds 5a2 and 5b2 were more effective than 5-FU.