1631040-56-6Relevant articles and documents
Gold(I) as an artificial cyclase: Short stereodivergent syntheses of (-)-epiglobulol and (-)-4β,7α- and (-)-4α,7α- aromadendranediols
Carreras, Javier,Livendahl, Madeleine,McGonigal, Paul R.,Echavarren, Antonio M.
supporting information, p. 4896 - 4899 (2014/05/20)
Three natural aromadendrane sesquiterpenes, (-)-epiglobulol, (-)-4β,7α-aromadendranediol, and (-)-4α,7α- aromadendranediol, have been synthesized in only seven steps in 12, 15, and 17% overall yields, respectively, from (E,E)-farnesol by a stereodivergent gold(I)-catalyzed cascade reaction which forms the tricyclic aromadendrane core in a single step. These are the shortest total syntheses of these natural compounds.
