16330-23-7

Basic information

• Product Name: 4-Pentyn-2-ol, 5-phenyl-
• Synonyms: 4-Pentyn-2-ol,5-phenyl;1-phenyl-1-pentyne-4-ol;5-Phenyl-4-pentyn-2-ol;1-Phenyl-1-pentyn-4-ol;1-Phenyl-pentin-(1)-ol-(4);5-phenyl-pent-4-yn-2-ol;5-Phenyl-pent-4-in-2-ol
• CAS NO: 16330-23-7
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Mol File: 16330-23-7.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 4-Pentyn-2-ol, 5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pentyn-2-ol, 5-phenyl-(16330-23-7)
• EPA Substance Registry System: 4-Pentyn-2-ol, 5-phenyl-(16330-23-7)

Safety Data

• Hazardous Substances Data: 16330-23-7(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 109-77-3 malononitrile 
• 75-56-9 methyloxirane 
• 591-50-4 iodobenzene 
• 2117-11-5 4-pentyn-2-ol 
• 2001-45-8 tetraphenyl phosphonium chloride 
• 5689-83-8 4-methyl-[1,3,2]dioxathiolane 2,2-dioxide 
• 4440-01-1 lithium phenylacetylide 
• 6738-06-3 phenylethynylmagnesium bromide 

Downstream Products

• 101028-21-1 (Z)-1,4-Dioxo-1-phenyl-2-pentene 
• 54444-26-7 2-methyl-4,5-diphenyl-2,3-dihydrofuran 
• 1384458-53-0 (E)-5-phenylpent-4-en-2-yl 4-methylbenzenesulfonate 
• 2344-71-0 5-phenylpentan-2-ol 
• 54985-29-4 (Z)-5-Phenyl-4-penten-2-ol 
• 4457-59-4 tetrahydro-2-methyl-5-phenylfuran 
• 4457-59-4 (2R*,5S*)-2-methyl-5-phenyltetrahydrofuran 

Relevant articles and documents

A copper-catalyzed reaction between terminal alkynes, acetylenic esters, and oxiranes: efficient synthesis of 2H-pyran-4-carboxylate

Abstract: A catalytic reaction between terminal alkynes, acetylenic esters, and oxiranes has been described. This domino transformation serves as a useful sequential and one-pot method for the synthesis of 2H-pyran-4-carboxylate skeletons from the readily available starting materials. In situ-generated copper acetylides treated initially with oxiranes in the presence of copper catalysts and tetrabutylphosphonium salts, followed by addition of propiolates after 60?min to form synthetically important heterocycles. Graphic abstract: [Figure not available: see fulltext.]

Copper Salt Catalyzed Synthesis of Functionalized 2H-Pyranes

A copper-catalyzed reaction between terminal alkynes, oxiranes, and malonitrile has been described. In this transformation, copper acetylide was attacked on oxiranes to form homopropargyl alkoxy-copper intermediate that was further transferred to 2H-pyrane skeletons by reaction with malonitrile. We found that the reaction was not productive without hexafluoroisopropanol.

Distal Alkenyl C-H Functionalization via the Palladium/Norbornene Cooperative Catalysis

A distal-selective alkenyl C-H arylation method is reported through a directed palladium/norbornene (Pd/NBE) cooperative catalysis. The key is to use an appropriate combination of the directing group and the NBE cocatalyst. A range of acyclic and cyclic c