163336-50-3Relevant articles and documents
Green preparation process of 2-methyl-3-methoxybenzoyl chloride
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Paragraph 0026, (2021/07/14)
The invention discloses a green preparation process of 2-methyl-3-methoxybenzoyl chloride. The green preparation process comprises the following steps: heating and hydrolyzing methyl 2-methyl-3-methoxybenzoate in an alkaline aqueous solution, and distilling off generated methanol while a hydrolysis reaction is carried out; adding an organic solvent into hydrolyzed reaction liquid under the condition of heat preservation for dissolving, and adding an acidic aqueous solution for neutralizing; conducting neutralizing, then preserving heat and conducting layering to obtain a water layer and an organic layer, and washing the organic layer with water; heating the washed organic layer for azeotropic water removal; and adding a catalyst into the organic layer after azeotropic dehydration, carrying out heating, dropwise adding an acylating chlorination reagent, and carrying out a heat-preserved reaction to obtain the 2-methyl-3-methoxybenzoyl chloride. In a neutralization process after hydrolysis is completed, the organic solvent is added, and the product 2-methyl-3-methoxybenzoic acid is transferred into the organic solvent and is transferred to a subsequent reaction in a solution state, so water consumption for post-treatment is reduced, and meanwhile, harm to a working environment and the health of workers in the solid dust drying and feeding process is avoided.
Synthesis and bioactivity of N-tert-butyl-N′-acyl-5-methyl-1,2,3- thiadiazole-4-carbohydrazides
Mao, Wu Tao,Zhao, Hui,Fan, Zhi Jin,Ji, Xiao Tian,Hua, Xue Wen,Kalinina, Tatiana,Yury, Yu. Morzherin,Vasiliy, A. Bakulev
, p. 1233 - 1236,4 (2020/10/15)
A series of novel N-tert-butyl-N′-acyl-5-methyl-1,2,3-thiadiazole-4- carbohydrazides were designed and synthesized. Their structures were characterized by melting points, 1H NMR, IR, ESI-MS, and elemental analysis. The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in vivo at 50 μg/mL, which was better than that of Ninamycin and tiadinial. Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development.
Process for the preparation of 3-Alkoxy-2-methylbenzoic acids
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Page 8, (2010/02/05)
Preparation of 3-alkoxy-2-methyl-benzoic acid compounds (I) involves: (a) reacting a naphthalene compound with alkali metal hydroxide in presence of water; (b) partially neutralizing; (c) treating with an alkyl halide, alkyl sulfonate or alkyl sulfate and (d) acidifying. Preparation of 3-alkoxy-2-methyl-benzoic acids of formula (I) involves: (a) reacting a naphthalene derivative of formula (III) with alkali metal hydroxide in presence of water; (b) partially neutralizing the reaction mixture (optionally after adding water, removing insolubles and/or removing undesirable soluble components); (c) reacting the mixture with an alkyl halide of formula R1X (IVa), an alkyl sulfonate of formula R1-OSO2-R8 (IVb) or a dialkyl sulfate of formula R1OSO2OR1 (IVc); and (d) acidifying the mixture. R1 = 1-14C alkyl, 7-20C aralkyl, 13-20C diarylalkyl, A-OR2 or A-NR3R4; A = 1-4C alkylene; R2, R3, R4 = Me, Et or isopropyl; R5-R7 = H, OH, NH2 or SO3M; M = H, ammonium, alkali metal or 1 equivalent of alkaline earth metal; X = Cl, Br or I, and R8 = 1-4C alkyl, 1-4C perfluoroalkyl, phenyl or p-tolyl.