163359-08-8

Basic information

• Product Name: 1-methylanthra[1,9-cd]pyrazol-6(1H)-one
• CAS NO: 163359-08-8
• Molecular Weight: 234.257
• Mol File: 163359-08-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-methylanthra[1,9-cd]pyrazol-6(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylanthra[1,9-cd]pyrazol-6(1H)-one(163359-08-8)
• EPA Substance Registry System: 1-methylanthra[1,9-cd]pyrazol-6(1H)-one(163359-08-8)

Safety Data

• Hazardous Substances Data: 163359-08-8(Hazardous Substances Data)

Upstream product

• 120093-15-4 1,9-pyrazoloanthrone 
• 80-48-8 methyl p-toluene sulfonate 
• 77-78-1 dimethyl sulfate 
• 129-56-6 2H-dibenzo[cd,g]indazol-6-one 

Relevant articles and documents

Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK)

N-Alkyl substituted pyrazoloanthrone derivatives were synthesized, characterized and tested for their in vitro inhibitory activity over c-Jun N-terminal kinase (JNK). Among the tested molecules, a few derivatives showed significant inhibitory activity against JNK with minimal off-target effect on other mitogen-activated protein kinase (MAP kinase) family members such as MEK1/2 and MKK3,6. These results suggested that N-alkyl (propyl and butyl) bearing pyrazoloanthrone scaffolds provide promising therapeutic inhibitors for JNK in regulating inflammation associated disorders. This journal is