163381-14-4

Basic information

• Product Name: (5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl benzoate
• Synonyms: (5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl benzoate
• CAS NO: 163381-14-4
• Molecular Weight: 388.461
• Mol File: 163381-14-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl benzoate(163381-14-4)
• EPA Substance Registry System: (5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl benzoate(163381-14-4)

Safety Data

• Hazardous Substances Data: 163381-14-4(Hazardous Substances Data)

Upstream product

• 63968-64-9 C₁₂H₁₃O₂(CH₃)3(O)(OO) 
• 98-88-4 benzoyl chloride 
• 71939-50-9 dihydroartemisinin 
• 71939-50-9 dihydroartemisinin 
• 65-85-0 benzoic acid 
• 545-06-2 trichloroacetonitrile 
• 82596-25-6 10α-dihydroartemisinyl benzoate 

Downstream Products

• 82596-30-3 9,10-dehydrodihydroartemisinin 
• 150358-71-7 bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether 
• 204503-64-0 10α-(2',4'-dimethoxyphenyl)-10-deoxo-10-dihydroartemisin 
• 350819-87-3 C₂₃H₃₂O₆ 
• 204503-68-4 10α-(2'-furyl)-10-deoxo-10-dihydroartemisinin 

Relevant articles and documents

Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers

In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by

Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

A series of novel hybrids of artemisinin (ART) with either a phytormone endoperoxide G factor analogue (GMeP) or chloroquine (CQ) and conjugates of the same compounds with the polyamines (PAs), spermidine (Spd), and homospermidine (Hsd) were synthesized and their antiplasmodial activity was evaluated using the CQ-resistant P. falciparum FcB1/Colombia strain. The ART-GMeP hybrid 5 and compounds 9 and 10 which are conjugates of Spd and Hsd with two molecules of ART and one molecule of GMeP, were the most potent with IC50 values of 2.6, 8.4, and 10.6 nM, respectively. The same compounds also presented the highest selectivity indexes against the primary human fibroblast cell line AB943 ranging from 16 372 for the hybrid 5 to 983 for the conjugate 10 of Hsd.