163462-16-6 Usage
Description
[S-(R,S)]-Phenylmethyl [1-oxiranyl-2-(phenylthio)ethyl]carbamate is a complex organic compound with a carbamate functional group. It is characterized by its unique structure, which includes a phenylmethyl group, a phenylthio group, and an oxiranyl group. [S-(R,S)]-Phenylmethyl [1-oxiranyl-2-(phenylthio)ethyl]carbamate is known for its potential applications in the pharmaceutical and chemical industries due to its versatile chemical properties.
Uses
Used in Pharmaceutical Industry:
[S-(R,S)]-Phenylmethyl [1-oxiranyl-2-(phenylthio)ethyl]carbamate is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in the Preparation of HIV Protease Inhibitors:
In the pharmaceutical industry, [S-(R,S)]-Phenylmethyl [1-oxiranyl-2-(phenylthio)ethyl]carbamate is used as a crucial intermediate for the preparation of HIV protease inhibitors. These inhibitors play a vital role in the treatment of HIV by blocking the activity of the HIV protease enzyme, which is essential for the replication of the virus.
Used in the Synthesis of Antibacterial Agents:
[S-(R,S)]-Phenylmethyl [1-oxiranyl-2-(phenylthio)ethyl]carbamate is also utilized in the synthesis of antibacterial agents targeting Streptococcus bacteria. Its incorporation into the structure of these agents helps enhance their effectiveness against bacterial infections, particularly those caused by Streptococcus species.
Check Digit Verification of cas no
The CAS Registry Mumber 163462-16-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,4,6 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 163462-16:
(8*1)+(7*6)+(6*3)+(5*4)+(4*6)+(3*2)+(2*1)+(1*6)=126
126 % 10 = 6
So 163462-16-6 is a valid CAS Registry Number.
163462-16-6Relevant articles and documents
Merging lithium carbenoid homologation and enzymatic reduction: A combinative approach to the HIV-protease inhibitor Nelfinavir
Castoldi, Laura,Ielo, Laura,Hoyos, Pilar,Hernáiz, María J.,De Luca, Laura,Alcántara, Andrés R.,Holzer, Wolfgang,Pace, Vittorio
, p. 2211 - 2217 (2018/03/28)
An effective stereocontrolled synthesis of the HIV protease inhibitor Nelfinavir is reported. Two transformations were identified crucial for achieving success: the formation of a densely functionalized α-chloroketone via the homologation of a Weinreb ami
INTERMEDIATES USEFUL IN THE SYNTHESIS OF HIV-PROTEASE INHIBITORS AND METHODS FOR PREPARING THE SAME
-
Page 36-37, (2010/02/09)
Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed (Formula I).
(1S)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylammonium benzoate, a versatile building block for chiral 2-aminoalkanols: Concise synthesis and application to nelfinavir, a potent HIV-protease inhibitor
Inaba, Takashi,Yamada, Yasuki,Abe, Hiroyuki,Sagawa, Shoichi,Cho, Hidetsura
, p. 1623 - 1628 (2007/10/03)
A concise synthesis of a versatile chiral C4 building block for 2- aminoalkanols, (1S)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]2- hydroxyethylammonium benzoate (1a), was described. 1 (1a and its enantiomener 1b) acted as four stereoisomers of optically active 2-amino-1,3,4- butanetriol. The versatility of 1 was demonstrated by its application to the practical synthesis of nelfinavir (2), a potent HIV-protease inhibitor, as well as by the stereospecific synthesis of three diastereomers of 2.
