163487-07-8

Basic information

• Product Name: (E)-1-(2-methoxyvinyl)-3-nitrobenzene
• Synonyms: (E)-1-(2-methoxyvinyl)-3-nitrobenzene
• CAS NO: 163487-07-8
• Molecular Weight: 179.175
• Mol File: 163487-07-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-1-(2-methoxyvinyl)-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-methoxyvinyl)-3-nitrobenzene(163487-07-8)
• EPA Substance Registry System: (E)-1-(2-methoxyvinyl)-3-nitrobenzene(163487-07-8)

Safety Data

• Hazardous Substances Data: 163487-07-8(Hazardous Substances Data)

Upstream product

• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 66146-33-6 2-(3-nitrophenyl)acetaldehyde 
• 1349744-92-8 N-(4-fluorobenzyl)-2-(3-nitrophenyl)ethanamine 
• 1349744-94-0 tert-butyl 4-fluorobenzyl-(3-nitrophenethyl)carbamate 
• 1349744-95-1 tert-butyl 3-aminophenethyl(4-fluorobenzyl)carbamate 
• 1349744-97-3 tert-butyl (3-(3-(5-cyanopyrazin-2-yl)ureido)phenyl)ethyl(4-fluorobenzyl)carbamate 
• 1349743-44-7 1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea 

Relevant articles and documents

Synthesis of Substrates for Aldolase-Catalysed Reactions: A Comparison of Methods for the Synthesis of Substituted Phenylacetaldehydes

Methods for the synthesis of phenylacetaldehydes (oxidation, one-carbon chain extension) were compared by using the synthesis of 4-methoxyphenylacetaldehyde as a model example. Oxidations of 4-methoxyphenylethanol with activated DMSO (Swern oxidation) or manganese dioxide gave unsatisfactory results; whereas oxidation with 2-iodoxybenzoic acid (IBX) produced 4-methoxyphenylacetaldehyde in reasonable (75%) yield. However, Wittig-type one-carbon chain extension with methoxymethylene-triphenylphosphine followed by hydrolysis gave an excellent (81% overall) yield of 4-methoxyphenylacetaldehyde from 4-methoxybenzaldehyde (a cheap starting material). This approach was subsequently used to synthesise a set of 10 substituted phenylacetaldehydes in good to excellent yields.