163490-78-6 Usage
Description
ETPI HCL, also known as EPIT, is a selective and competitive inhibitor of neuronal nitric oxide synthase (nNOS or NOS I) with a Ki of 0.32 μM for the purified human enzyme. It is a white to off-white solid and exhibits a high degree of selectivity for nNOS compared to inducible nitric oxide synthase (iNOS or NOS II) and endothelial nitric oxide synthase (eNOS or NOS III), with 115-fold and 29-fold selectivity, respectively. ETPI HCL also binds competitively with L-Arginine, a key substrate in the nitric oxide synthase reaction.
Uses
Used in Pharmaceutical Industry:
ETPI HCL is used as a selective inhibitor for nNOS in the pharmaceutical industry for its potential therapeutic applications in various conditions. Its high selectivity for nNOS over iNOS and eNOS makes it a valuable tool in the development of targeted treatments.
Used in Research Applications:
In the field of scientific research, ETPI HCL is used as a research tool to study the role of nNOS in various biological processes and diseases. Its competitive binding with L-Arginine allows researchers to investigate the effects of nNOS inhibition on cellular and molecular levels.
Used in Drug Development:
ETPI HCL is utilized in drug development as a lead compound or a reference standard for the design and synthesis of new nNOS inhibitors. Its high selectivity and potency make it an attractive starting point for the development of novel therapeutic agents targeting nNOS-related conditions.
Used in Neurological Applications:
ETPI HCL is used as a selective nNOS inhibitor in neurological applications, where it can help modulate nitric oxide production and potentially provide therapeutic benefits in conditions such as neurodegenerative diseases, stroke, and migraine.
Used in Cardiovascular Applications:
In the cardiovascular field, ETPI HCL is used as a selective nNOS inhibitor to study its potential role in regulating vascular tone, blood pressure, and other cardiovascular functions. Its selective inhibition of nNOS may offer insights into the development of targeted therapies for cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 163490-78-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,4,9 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 163490-78:
(8*1)+(7*6)+(6*3)+(5*4)+(4*9)+(3*0)+(2*7)+(1*8)=146
146 % 10 = 6
So 163490-78-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H11F3N2S.ClH/c1-2-16-9(14)15-8-5-3-7(4-6-8)10(11,12)13;/h3-6H,2H2,1H3,(H2,14,15);1H
