1635-84-3 Usage
Description
4,6-DIMETHYL-2-NITROANILINE is an organic compound that belongs to the class of aromatic amines. It is characterized by the presence of a nitro group (-NO2) at the 2nd position and two methyl groups (-CH3) at the 4th and 6th positions on a benzene ring. 4,6-DIMETHYL-2-NITROANILINE is known for its chemical reactivity and is often utilized in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
4,6-DIMETHYL-2-NITROANILINE is used as a reagent for the synthetic preparation of 1,2-bis-substituted benzimidazoles, which are nonnucleoside HIV-1 reverse transcriptase inhibitors. These inhibitors play a crucial role in the development of antiretroviral drugs, as they help in the treatment of HIV and AIDS by blocking the replication of the virus.
In the synthesis process, 4,6-DIMETHYL-2-NITROANILINE serves as a key intermediate, providing the necessary structural features required for the formation of the final benzimidazole product. The compound's reactivity and functional groups enable it to undergo various chemical reactions, such as nucleophilic substitution, electrophilic aromatic substitution, and reduction, which are essential for the synthesis of the desired benzimidazole derivatives.
The development of nonnucleoside HIV-1 reverse transcriptase inhibitors is of great importance in the fight against HIV and AIDS, as these drugs offer an alternative treatment option for patients who may not respond well to or cannot tolerate other antiretroviral medications. By using 4,6-DIMETHYL-2-NITROANILINE as a reagent in the synthesis of these inhibitors, researchers can explore new chemical structures and potentially discover more effective and safer drugs to combat the virus.
Check Digit Verification of cas no
The CAS Registry Mumber 1635-84-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,3 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1635-84:
(6*1)+(5*6)+(4*3)+(3*5)+(2*8)+(1*4)=83
83 % 10 = 3
So 1635-84-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O2/c1-5-3-6(2)8(9)7(4-5)10(11)12/h3-4H,9H2,1-2H3
1635-84-3Relevant articles and documents
Indole and indazole compounds as an inhibitor of cellular necrosis
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Paragraph 0406; 0407, (2016/10/08)
The present invention refers to a formula (1) compounds of, pharmaceutically acceptable salts or isomers thereof thereof, and characterized by by containing as active ingredients-associated diseases, cell death and method for the prevention or treatment of relates and compositions. [Formula 1] In formula said R 1, R 2, R 3, R 4, R 5, R 6, A, X, n and m to equal the specification.
Green recyclable CuO-CeO2 nanocomposite catalyzed amination of aryl halides with aqueous ammonia in water
Albadi, Jalal,Mansournezhad, Azam
, p. 396 - 398 (2014/06/10)
CuO-CeO2 nanocomposite as a green recyclable catalyst, catalyzed amination of aryl halides with aqueous ammonia in water. This catalyst can be easily recovered by simple filtration and recycled up to 5 consecutive runs with consistent activity. The procedure provides some advantages such as simple work-up, clean procedure, relatively short reaction times and high yields of the products. Efficient procedure for the amination of aryl halides catalyzed by Cu-CeO2 nanocomposite. Copyright
INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS
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Page/Page column 33; 52-53, (2009/04/25)
The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
