1636135-00-6Relevant articles and documents
Synthesis of oxygenated chalcones with anti-staphylococcal activity
Dalla-Vechia, Luciana,Kiekow, Cíntia Janine,Leal, Ivana Correa Ramos,Dos Santos, Katia Regina Netto,Gnoatto, Simone Cristina Baggio,Verli, Hugo,De Souza, Rodrigo Octavio Mendon?a Alves,Gosmann, Grace
, p. 525 - 530 (2014/05/20)
Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3',5',4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 μg/ml to a multidrug-resistant hospital clinical strain of S. aureus.
