163733-99-1 Usage
Description
4-Amino-2,3-difluorophenol is a chemical compound that is one of the metabolites of 4-aminophenol. It is characterized by the presence of an amino group attached to a phenol ring, with two fluorine atoms substituting the 2nd and 3rd positions on the ring. 4-AMINO-2,3-DIFLUORO-PHENOL is a brown to black powder and is used in various applications due to its unique chemical properties.
Uses
Used in Environmental Research:
4-Amino-2,3-difluorophenol is used as a research compound in the field of environmental science, specifically for studying dehalogenation processes. Dehalogenation is an important process in the degradation of halogenated organic compounds, which are often found as environmental pollutants. Understanding the role of 4-amino-2,3-difluorophenol in dehalogenation can help in developing strategies for the remediation of contaminated sites and the management of hazardous waste.
Used in Chemical Synthesis:
4-Amino-2,3-difluorophenol can be used as a building block or intermediate in the synthesis of various organic compounds. Its unique structure, with the amino and fluorine substituents on the phenol ring, makes it a valuable precursor for the development of new pharmaceuticals, agrochemicals, and other specialty chemicals. 4-AMINO-2,3-DIFLUORO-PHENOL's reactivity and stability can be exploited in various chemical reactions, such as nucleophilic substitution, electrophilic aromatic substitution, and cross-coupling reactions, to produce a wide range of target molecules.
Used in Material Science:
The unique properties of 4-amino-2,3-difluorophenol, such as its electronic and steric effects, make it a potential candidate for the development of new materials with specific properties. For example, it can be used in the synthesis of novel polymers, dyes, or sensors with tailored characteristics. The incorporation of 4-amino-2,3-difluorophenol into these materials can lead to improved performance, such as enhanced stability, selectivity, or sensitivity, depending on the application.
Used in Pharmaceutical Research:
Due to its structural features, 4-amino-2,3-difluorophenol can be a valuable compound in the search for new drugs and drug candidates. Its ability to form hydrogen bonds and its potential to interact with biological targets make it an interesting starting point for the design of new therapeutic agents. Researchers can use this compound as a template to develop new drugs with improved pharmacological properties, such as better potency, selectivity, or reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 163733-99-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,7,3 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 163733-99:
(8*1)+(7*6)+(6*3)+(5*7)+(4*3)+(3*3)+(2*9)+(1*9)=151
151 % 10 = 1
So 163733-99-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H5F2NO/c7-5-3(9)1-2-4(10)6(5)8/h1-2,10H,9H2
163733-99-1Relevant articles and documents
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor
Zhang, Hefeng,Peng, Xia,Dai, Yang,Shao, Jingwei,Ji, Yinchun,Sun, Yiming,Liu, Bo,Cheng, Xu,Ai, Jing,Duan, Wenhu
, p. 3956 - 3975 (2021/04/12)
The receptor tyrosine kinase Axl plays important roles in promoting cancer progression, metastasis, and drug resistance and has been identified as a promising target for anticancer therapeutics. We used molecular modeling-assisted structural optimization starting with the low micromolar potency compound 9 to discover compound 13c, a highly potent and orally bioavailable Axl inhibitor. Selectivity profiling showed that 13c could inhibit the well-known oncogenic kinase Met with equal potency to its inhibition of Axl superfamily kinases. Compound 13c significantly inhibited cellular Axl and Met signaling, suppressed Axl- and Met-driven cell proliferation, and restrained Gas6/Axl-mediated cancer cell migration or invasion. Furthermore, 13c exhibited significant antitumor efficacy in Axl-driven and Met-driven tumor xenograft models, causing tumor stasis or regression at well-tolerated doses. All these favorable data make 13c a promising therapeutic candidate for cancer treatment.
SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE
-
, (2014/02/16)
The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE
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, (2014/01/07)
The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
