163759-50-0

Basic information

• Product Name: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine
• Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine;5'-O-DMTr- 2'-O-(2-Methoxyethyl)-5-Methyl- uridine;5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)-5-methyluridine;1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;2'-O-(2-Methoxyethyl)-5'-O-bis(4-methoxypheny)phenylmethy-5-methyluridine, 97%
• CAS NO: 163759-50-0
• Molecular Formula: C₃₄H₃₈N₂O₉
• Molecular Weight: 618.67352
• Mol File: 163759-50-0.mol
• Article Data: 413

Chemical Properties

• Appearance: /
• Density: 1.32
• PKA: 9.55±0.10(Predicted)
• CAS DataBase Reference: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine(163759-50-0)
• EPA Substance Registry System: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine(163759-50-0)

Safety Data

• Hazardous Substances Data: 163759-50-0(Hazardous Substances Data)

Usage

Description

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine, also known as U829910, is a protected uridine derivative and nucleoside used in the preparation of synthetic nucleic acids. It features a unique structure with modifications at the 5' and 2' positions, which contribute to its stability and reactivity in various chemical and biological processes.

Uses

Used in Pharmaceutical Industry:
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine is used as a building block for the synthesis of nucleic acid analogs for the development of new drugs and therapeutic agents. Its unique structure allows for the creation of modified nucleic acids with improved properties, such as enhanced stability, target specificity, and reduced immunogenicity.
Used in Research and Development:
In the field of research and development, 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine serves as a valuable tool for studying the structure, function, and interactions of nucleic acids. Its protected nature allows for controlled synthesis and modification, facilitating the exploration of novel nucleic acid-based technologies and applications.
Used in Diagnostics:
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine can be employed in the development of diagnostic tools and assays, such as qPCR, FISH, and other molecular biology techniques. Its unique structure and properties can enhance the sensitivity, specificity, and reliability of these diagnostic methods.
Used in Biomaterials and Drug Delivery:
The protected uridine derivative can also be utilized in the design and fabrication of biomaterials and drug delivery systems. Its chemical and biological properties can be harnessed to create materials with controlled release, targeted delivery, and improved biocompatibility.
Used in Nanotechnology:
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine has potential applications in nanotechnology, where it can be integrated into nanostructures and devices for various purposes, such as drug delivery, imaging, and sensing. Its unique structure and properties can contribute to the development of innovative nanotechnological solutions.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 67-56-1 methanol 
• 163759-49-7 2'-O-(2-methoxyethyl)-5-methyluridine 
• 98-07-7 Benzotrichlorid 
• 100-66-3 methoxybenzene 
• 40615-35-8 4,4'-dimethoxytrityl alcohol 
• 1463-10-1 5-Methyluridine 
• 26879-47-0 1-(β-L-ribofuranosyl)thymine 
• 22423-26-3 O-2,2'-cyclo-5-methyluridine 
• 14983-42-7 tris(2-methoxyethyl)borate 
• 854751-16-9 chloro-bis-(2-methoxy-phenyl)-phenyl-methane 
• 730979-83-6 MOE T DMT succinate 
• 163759-46-4 3-Benzyloxymethyl-1-[(2R,3R,4R,5R)-4-(2,4-dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 163759-44-2 1-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-3-<(benzyloxy)methyl>thymin 

Downstream Products

• 730979-83-6 MOE T DMT succinate 
• 1221967-92-5 C₁₉H₃₄N₂O₇Si 
• 163759-94-2 MOE 5-Me-C Amidite 
• 1345564-47-7 C₂₉H₃₆N₂O₇Si 
• 844504-17-2 2'-O-(2-methoxy)ethyl-3'-O-(t-butyldiphenyl)silylthymidine 

Relevant articles and documents

Copper(II)nitrate catalyzed regioselective protection of primary alcohols with 4,4′-dimethoxytrityl and 2,7-dimethyl-9-phenyl xanthen-9-yl groups in nucleosides and carbohydrates

Regioselective protection of primary hydroxyl group in nucleoside and carbohydrate analogs was accomplished using dimethoxytrityl alcohol (DMTr-OH) or dimethylpixyl alcohol (DMPx-OH) in presence of copper(II)nitrate as a Lewis acid catalyst. Excellent selectivity was observed for the protection of primary hydroxyl group over secondary while glycosidic bond remain unaffected. Utility of this methodology was further exemplified via DMTr- and DMPx-protection of alipahtic acyclic and cyclic diols.

EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS

Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided. Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process.

Antisense modulation of CD40 ligand expression

Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.