1638156-42-9

Basic information

• Product Name: 4-ethynyl-2,5-bis(4-nitrophenyl)pyrimidine
• Synonyms: 4-ethynyl-2,5-bis(4-nitrophenyl)pyrimidine
• CAS NO: 1638156-42-9
• Molecular Weight: 346.302
• Mol File: 1638156-42-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-ethynyl-2,5-bis(4-nitrophenyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethynyl-2,5-bis(4-nitrophenyl)pyrimidine(1638156-42-9)
• EPA Substance Registry System: 4-ethynyl-2,5-bis(4-nitrophenyl)pyrimidine(1638156-42-9)

Safety Data

• Hazardous Substances Data: 1638156-42-9(Hazardous Substances Data)

Upstream product

• 50434-36-1 4-nitrophenylacetyl chloride 
• 52708-02-8 4-nitrobenzimidic acid methyl ester 
• 619-72-7 4-nitrobenzonitrile 
• 1416159-19-7 (1E)-1-ethoxy-2-(4-nitrophenyl)-5-(trimethylsilyl)pent-1-en-4-yn-3-one 
• 15723-90-7 4-nitrobenzamidine hydrochloride 
• 1357356-72-9 1-(4-nitrophenyl)-4-(trimethylsilyl)but-3-yn-2-one 

Relevant articles and documents

Transition-metal-free approach to 4-ethynylpyrimidines via alkenynones

A practical approach to the synthesis of 4-ethynylpyrimidines by the condensation of arylamidines with 2-aryl-1-ethoxy-5-(trimethylsilyl)pent-1-en-4- yn-3-ones has been developed. As these latter ketones are easily accessible from bis(trimethylsilyl)acetylene and arylacetyl chlorides, the regioselective condensation reported herein provides a facile access to both TMS-protected and unprotected 4-ethynylpyrimidines in yields of up to 85%. Copyright