16386-34-8

Basic information

• Product Name: METHYL (E)-3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOATE
• Synonyms: METHYL 3-(1,3-BENZODIOXOL-5-YL)ACRYLATE;METHYL (E)-3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOATE
• CAS NO: 16386-34-8
• Molecular Formula: C₁₁H₁₀O₄
• Molecular Weight: 206.19
• Mol File: 16386-34-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL (E)-3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (E)-3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOATE(16386-34-8)
• EPA Substance Registry System: METHYL (E)-3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOATE(16386-34-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 16386-34-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 821775-38-6 3-(3′,4′-methylenedioxophenyl)propenal 
• 94-59-7 1-allyl-3,4-methylenedioxybenzene 
• 4043-71-4 isosafrole 
• 120-57-0 piperonal 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 5927-18-4 trimethyl phosphonoacetate 
• 331-39-5 caffeic acid 
• 74-95-3 1,1-dibromomethane 
• 77-76-9 2,2-dimethoxy-propane 
• 2373-80-0 3,4-(methylenedioxy)cinnamic acid 

Relevant articles and documents

Asymmetric synthesis of piperidines using the nitro-Mannich reaction☆

A method for the synthesis of functionalized piperidines containing 3 contiguous stereocentres in the 2-,3- and 4- positions uses a diastereoselective nitro-Mannich to control stereochemistry. The nitro-Mannich reaction between a β-aryl/heteroaryl substituted nitroalkanes and glyoxylate imine provides β-nitro-amines with good selectivity (70:30 to >95:5) for the syn, anti-diastereoisomers. Reductive cyclisation with BF3.OEt2 and Et3SiH gave, after purification, stereochemically pure piperidines in 19–57% yield for ten examples with different 4-aryl/heteroaryl substituents.

Scope of the formal [3+2] cycloaddition for the synthesis of five-membered ring of functionalized indanes

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