163956-01-2

Basic information

• Product Name: 3-demethyl-3-(2,3,4,5-tetra-O-acetyl-β-D-glucopyranosyl)thiocolchicine
• Synonyms: 3-demethyl-3-(2,3,4,5-tetra-O-acetyl-β-D-glucopyranosyl)thiocolchicine
• CAS NO: 163956-01-2
• Molecular Weight: 731.775
• Mol File: 163956-01-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-demethyl-3-(2,3,4,5-tetra-O-acetyl-β-D-glucopyranosyl)thiocolchicine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-demethyl-3-(2,3,4,5-tetra-O-acetyl-β-D-glucopyranosyl)thiocolchicine(163956-01-2)
• EPA Substance Registry System: 3-demethyl-3-(2,3,4,5-tetra-O-acetyl-β-D-glucopyranosyl)thiocolchicine(163956-01-2)

Safety Data

• Hazardous Substances Data: 163956-01-2(Hazardous Substances Data)

Upstream product

• 87424-25-7 3-O-demethylthiocolchicine 
• 604-69-3 β-D-glucose pentaacetate 
• 439-03-2 2,3,4,6-tetra-O-acetyl-1-fluoro-α-D-glucopyranose 

Downstream Products

• 602-41-5 thiocolchicoside 
• 939373-74-7 6'-thioacetylthiocolchicoside triacetate 
• 939373-71-4 6'-iodothiocolchicoside triacetate 
• 939373-69-0 6'-tosylthiocolchicoside triacetate 
• 939373-68-9 6'-tosylthiocolchicoside 

Relevant articles and documents

Novel 3-O-glycosyl-3-demethylthiocolchicines as ligands for glycine and γ-aminobutyric acid receptors

New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on γ-aminobutyric acid (GABA) and strychnine-sensitive glycine receptors present in rat brain and spinal cord. Two different synthetic approaches were used with the readily available 3-O-demethylthiocolchicine (1b) and thiocolchicoside (2a). Glycosyl compounds 2a-g were obtained from 1b and 1-fluorosugars 4. 6′-Heterosubstituted glycosyl compounds 6-12 and the 6′-desoxy derivative 2h were prepared from 2a.