16398-07-5Relevant articles and documents
Identification of a novel non-carbohydrate molecule that binds to the ribosomal A-site RNA
Maddaford, Shawn P.,Motamed, Mina,Turner, Kevin B.,Choi, Min Soo K.,Ramnauth, Jailall,Rakhit, Suman,Hudgins, Robert R.,Fabris, Daniele,Johnson, Philip E.
, p. 5987 - 5990 (2004)
We report the identification of a novel compound that binds to the Escherichia coli ribosomal A-site. We observed binding using NMR, mass spectrometry, and docking techniques and demonstrate that the compound binds in the same position as occupied by amin
Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site
Meijer, Femke A.,Van Den Oetelaar, Maxime C. M.,Doveston, Richard G.,Sampers, Ella N. R.,Brunsveld, Luc
supporting information, p. 631 - 639 (2021/04/07)
The nuclear receptor RORγt is a key positive regulator in the differentiation and proliferation of T helper 17 (Th17) cells and the production of proinflammatory cytokines like IL-17a. Dysregulation of this pathway can result in the development of various
Thioimides: New reagents for effective synthesis of thiolesters from carboxylic acids
Henke, Adam,Srogl, Jiri
, p. 7783 - 7784 (2008/12/22)
(Chemical Equation Presented) Thioimides and carboxylic acids are used as the precursors for the convenient synthesis of thiolesters in the phosphine mediated process. Cyclic and acyclic thioimides show equal efficiency, furnishing the desired thiolesters in good to excellent yields. The general, highly efficient transformation tolerates various functional groups and the resulting thiolesters are obtained in high purity after a simple separation. The reaction scope has been demonstrated on the preparation of several highly functionalized target molecules.