163981-87-1

Basic information

• Product Name: (E)-1-<<(3,4-dimethoxyphenyl)methyl>methylamino>-4-(4-aminophenyl)but-2-ene
• Synonyms: (E)-1-<<(3,4-dimethoxyphenyl)methyl>methylamino>-4-(4-aminophenyl)but-2-ene
• CAS NO: 163981-87-1
• Molecular Weight: 326.439
• Mol File: 163981-87-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-<<(3,4-dimethoxyphenyl)methyl>methylamino>-4-(4-aminophenyl)but-2-ene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-<<(3,4-dimethoxyphenyl)methyl>methylamino>-4-(4-aminophenyl)but-2-ene(163981-87-1)
• EPA Substance Registry System: (E)-1-<<(3,4-dimethoxyphenyl)methyl>methylamino>-4-(4-aminophenyl)but-2-ene(163981-87-1)

Safety Data

• Hazardous Substances Data: 163981-87-1(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 63-64-9 N-methylveratrylamine 
• 163981-47-3 (E)-1-<<(3,4-dimethoxyphenyl)methyl>methylamino>-4-(4-nitrophenyl)but-2-ene 

Relevant articles and documents

Synthesis and Activity against Multidrug Resistance in Chinese Hamster Ovary Cells of New Acridone-4-carboxamides

A number of tricyclic carboxamides have been synthesized and tested to evaluate their ability to reverse multidrug resistance in the CHRC/5 cell line.Among them the acridone derivatives were the most potent.A key feature is the presence of a dimethoxybenzyl or phenethylamine cationic site, separated from the tricyclic lipophilic part by a carbamoylphenyl chain.Optimization led to compounds 2 orders of magnitude more active than the prototype inhibitors verapamil and amiodarone.On the basis of in vitro and in vivo activities, 9,10-dihydro-5-methoxy-9-oxo-N-phenyl>-4-acridinecarboxamide (84) has been selected for further development.