16400-50-3 Usage
Description
3,3',5,5'-TETRABROMOBIPHENYL, also known as PBB 80, is a brominated biphenyl compound related to PBB 37 (P215150). It is characterized by its chemical structure, which includes four bromine atoms attached to the biphenyl molecule. 3,3',5,5'-TETRABROMOBIPHENYL has various applications in different industries due to its unique properties.
Uses
Used in Flame Retardancy:
3,3',5,5'-TETRABROMOBIPHENYL is used as a flame retardant for enhancing the fire resistance of various consumer products. It is commonly incorporated into appliances, electronics, and plastics to reduce the risk of fire and improve safety.
Used in Organic Synthesis:
3,3',5,5'-TETRABROMOBIPHENYL serves as an organic synthesis intermediate, playing a crucial role in the development of new chemical compounds. Its unique structure allows for further chemical reactions and modifications, leading to the creation of a wide range of products.
Used in Pharmaceutical Industry:
As a pharmaceutical intermediate, 3,3',5,5'-TETRABROMOBIPHENYL is utilized in the research and development of new drugs. Its properties make it a valuable component in the synthesis of various pharmaceutical compounds, contributing to the advancement of medical treatments.
Used in Laboratory Research and Development:
3,3',5,5'-TETRABROMOBIPHENYL is also employed in laboratory research and development processes. Its unique chemical structure and properties make it an essential tool for scientists and researchers working on various projects, including the development of new materials, chemicals, and pharmaceuticals.
Used in Chemical Production Processes:
In the chemical production industry, 3,3',5,5'-TETRABROMOBIPHENYL is used as an intermediate in the manufacturing of various chemicals. Its versatility and unique properties make it a valuable component in the production of a wide range of chemical products.
Preparation
1,3,5-tribromobenzene (6.3 g, 20 mmol) was dissolved in diethylether (50 ml). The reaction solution was cooled to -78° C., and n-butyllithium (8.8 ml, 22 mmol, 2.5M in hexane) was gradually added thereto. The reaction mixture was stirred at -78° C. for one hour, and copper chloride (II) (2.96 g, 22 mmol) was added thereto at -78° C. The reaction solution was stirred for five hours and washed with distilled water and ethylacetate at room temperature. The obtained ethylacetate layer was dried over MgSO4, and then dried under a reduced pressure to obtain a crude product. The crude product was purified by silica gel column chromatography to give intermediate A as a white solid (3.74 g, yield: 80%).
Check Digit Verification of cas no
The CAS Registry Mumber 16400-50-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,4,0 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 16400-50:
(7*1)+(6*6)+(5*4)+(4*0)+(3*0)+(2*5)+(1*0)=73
73 % 10 = 3
So 16400-50-3 is a valid CAS Registry Number.
16400-50-3Relevant articles and documents
Sterically controlled C-H/C-H homocoupling of arenes: Via C-H borylation
Pei, Xiaocong,Zhou, Guan,Li, Xuejing,Xu, Yuchen,Panicker, Resmi C.,Srinivasan, Rajavel
supporting information, p. 5703 - 5707 (2019/06/19)
A mild one-pot protocol for the synthesis of symmetrical biaryls by sequential Ir-catalyzed C-H borylation and Cu-catalyzed homocoupling of arenes is described. The regiochemistry of the biaryl formed is sterically controlled as dictated by the C-H borylation step. The methodology is also successfully extended to heteroarenes. Some of the products obtained by this approach are impossible to obtain via the Ullmann or the Suzuki coupling protocols. Finally, we have shown a one-pot sequence describing C-H borylation/Cu-catalyzed homocoupling/Pd-catalyzed Suzuki coupling to obtain π-extended arene frameworks.
Oxidative homocoupling reaction of aryltrimethylsilanes by Pd/o-chloranil catalysis
Shibata, Mari,Ito, Hideto,Itami, Kenichiro
supporting information, p. 1701 - 1704 (2017/11/23)
A practical oxidative homocoupling reaction of aryltri-methylsilanes has been achieved by Pd/o-chloranil catalytic system. The reaction shows the good functional group tolerability toward bromo, fluoro, ester, and methoxy groups to give a series of biaryls bearing electron-withdrawing and -donating groups. The boronate group is also retained on biaryls without any ArB bond cleavage, which is highly advantageous for orthogonal coupling.
Tetraarylbiphenyl as a new lattice inclusion host by structure reductionism: Shape and size complementarity based on torsional flexibility
Neogi, Ishita,Bajpai, Alankriti,Savitha, Govardhan,Moorthy, Jarugu Narasimha
, p. 2129 - 2136 (2015/05/20)
3,3′,5,5′-Tetrakis(2,6-dimethyl-4-methoxyphenyl)biphenyl (TB) was designed as a lattice inclusion host based on a structure reductionistic approach. TB binds guests in two different domains based on the premise that the two phenyl rings of the biphenyl co
