164082-80-8

Basic information

• Product Name: 1H-Indole, 2-ethyl-4-methoxy-1-(phenylmethyl)-
• CAS NO: 164082-80-8
• Molecular Formula: C18H19NO
• Molecular Weight: 265.355
• Mol File: 164082-80-8.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 2-ethyl-4-methoxy-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2-ethyl-4-methoxy-1-(phenylmethyl)-(164082-80-8)
• EPA Substance Registry System: 1H-Indole, 2-ethyl-4-methoxy-1-(phenylmethyl)-(164082-80-8)

Safety Data

• Hazardous Substances Data: 164082-80-8(Hazardous Substances Data)

Upstream product

• 1048660-12-3 1-(1-benzyl-4-methoxy-1H-indol-2-yl)ethanol 
• 19500-02-8 2-methyl-3-methoxyaniline 
• 164082-78-4 1-[2-(tert-butoxycarbonylamino)-6-methoxyphenyl]-2-butanone 
• 164082-77-3 tert-butyl (3-methoxy-2-methylphenyl)carbamate 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 791642-67-6 1-chloro-2-iodo-3-methoxybenzene 
• 858854-82-7 3-chloro-2-iodo-phenol 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 863870-77-3 3-chloro-2-iodophenyl N,N-dimethyl O-carbamate 
• 945470-36-0 2-but-1-ynyl-1-chloro-3-methoxybenzene 
• 100-46-9 benzylamine 
• 100-39-0 benzyl bromide 
• 164082-79-5 2-Ethyl-4-methoxy-1H-indole 

Downstream Products

• 172733-06-1 1-benzyl-2-ethyl-1H-indol-4-ol 
• 185298-82-2 (S)-4-Benzyl-3-[(S)-2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)-propionyl]-oxazolidin-2-one 
• 185298-81-1 (S)-4-Benzyl-3-[(R)-2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)-propionyl]-oxazolidin-2-one 
• 1026845-15-7 (R)-2-(1-Benzyl-3-chlorooxalyl-2-ethyl-1H-indol-4-yloxy)-propionic acid methyl ester 
• 185298-55-9 methyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)propanoate 
• 185298-45-7 (S)-2-(1-Benzyl-2-ethyl-1H-indol-4-yloxy)-propionic acid methyl ester 
• 185298-43-5 (R)-2-(1-Benzyl-2-ethyl-1H-indol-4-yloxy)-propionic acid methyl ester 
• 185298-41-3 methyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)propanoate 
• 185298-54-8 2-(3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-4-phenyl-butyric acid methyl ester 
• 185299-10-9 (S)-2-(3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-propionic acid benzyl ester 
• 1026671-08-8 (S)-2-(1-Benzyl-3-chlorooxalyl-2-ethyl-1H-indol-4-yloxy)-propionic acid benzyl ester 
• 185298-59-3 (3-Aminooxalyl-1-benzyl-2-ethyl-5-propyl-1H-indol-4-yloxy)-acetic acid ethyl ester 
• 1026499-74-0 (1-Benzyl-3-chlorooxalyl-2-ethyl-1H-indol-4-ylsulfanyl)-acetic acid tert-butyl ester 
• 185298-18-4 (5-Allyl-3-aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-acetic acid ethyl ester 

Relevant articles and documents

Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2

We report a series of inhibitors of secreted phospholipases A2 (sPLA2s) based on substituted indoles, 6,7-benzoindoles, and indolizines derived from LY315920, a well-known indole-based sPLA2 inhibitor. Using the human group X sPLA2 crystal structure, we prepared a highly potent and selective indole-based inhibitor of this enzyme. Also, we report human and mouse group IIA and IIE specific inhibitors and a substituted 6,7-benzoindole that inhibits nearly all human and mouse sPLA 2s in the low nanomolar range.

PHARMACEUTICAL COMPOSITIONS CONTAINING THE PHOSPHOLIPASE INHIBITOR SODIUM 3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-PHENYLMETHYL)-1H-INDOL-4-YL]OXY]ACETATE

A lyophilized pharmaceutical composition is described which contains Sodium [[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-phenylmethyl)-1H-indol-4-yl]oxy]acetate, a Solubilizer, and a Stabilizer. Such compositions are storage stable and readily dissolve in aqueous medium to give injectable solution for treatment of sepsis, etc.

Novel sPLA2 inhibitors

A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.