164295-93-6 Usage
Description
5-NAPHTHALEN-2-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER, also known as Methyl 3-(2-naphthyl)-1H-pyrazole-5-carboxylate, is a chemical compound with a complex molecular structure. It is characterized by its naphthalene and pyrazole moieties, which contribute to its unique properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
5-NAPHTHALEN-2-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER is used as a reagent for synthesizing potent histone deacetylase inhibitors. These inhibitors have demonstrated in vitro and in vivo anti-tumor efficacy, making them valuable tools in the development of novel cancer treatments.
Application Reason:
The compound's ability to act as a reagent in the synthesis of histone deacetylase inhibitors is due to its unique molecular structure, which allows it to interact with and modulate the activity of these enzymes. By inhibiting histone deacetylases, the compound can potentially influence gene expression and cellular processes, leading to the suppression of tumor growth and the enhancement of cancer cell death.
Check Digit Verification of cas no
The CAS Registry Mumber 164295-93-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,2,9 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 164295-93:
(8*1)+(7*6)+(6*4)+(5*2)+(4*9)+(3*5)+(2*9)+(1*3)=156
156 % 10 = 6
So 164295-93-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H12N2O2/c1-19-15(18)14-9-13(16-17-14)12-7-6-10-4-2-3-5-11(10)8-12/h2-9H,1H3,(H,16,17)
164295-93-6Relevant articles and documents
Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles
Drikermann, Denis,G?rls, Helmar,Kerndl, Valerie,Vilotijevic, Ivan
, p. 1158 - 1162 (2020/07/20)
Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95percent. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- A nd tri-substituted pyrazoles. With the ability to produce highly substituted pyrazoles and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold and may be of interest to all branches of the chemical industry.
