16433-43-5

Basic information

• Product Name: 4-phenylpentanoic acid
• Synonyms: 4-Phenylpentanoic acid; benzenebutanoic acid, gamma-methyl-
• CAS NO: 16433-43-5
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.2277
• Mol File: 16433-43-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 13°C
• Boiling Point: 291.9°C at 760 mmHg
• Flash Point: 189.1°C
• Density: 1.066g/cm³
• Vapor Pressure: 0.000865mmHg at 25°C
• Refractive Index: 1.525
• PKA: 4.70±0.10(Predicted)
• CAS DataBase Reference: 4-phenylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenylpentanoic acid(16433-43-5)
• EPA Substance Registry System: 4-phenylpentanoic acid(16433-43-5)

Safety Data

• Hazardous Substances Data: 16433-43-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 74, p. 1591, 1952 DOI: 10.1021/ja01126a504

Upstream product

• 1612882-49-1 C₁₄H₁₈O₄ 
• 147514-19-0 S-(-)-1-bromo-2-phenylpropane 
• 51259-14-4 (R)?ethyl?4?phenylpentanoate 
• 1278571-73-5 (R)?diethyl?2?(2?phenylpropyl)malonate 
• 34713-70-7 2-Phenylpropanal 
• 223243-86-5 (E)-4-phenyl-3-pentenoic acid 
• 2031-46-1 (R)-3-phenylbutanol 
• 772-14-5 (R)-3-phenylbutyric acid 
• 124-38-9 carbon dioxide 
• 36617-72-8 (-)-(R)-1-Chlor-2-phenyl-butan 
• 5747-06-8 4-phenylpent-4-enoic acid 
• 2051-95-8 succinylbenzene 
• 1459-00-3 1-bromo-2-phenylpropane 
• 4469-66-3 4-Phenyl-2-methoxycarbonyl-4-enoic acid methyl ester 

Downstream Products

• 34601-30-4 2-Ethyl-allenylbenzol 
• 4175-54-6 1,2,3,4-tetrahydro-1,4-dimethylnaphthalene 

Relevant articles and documents

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Non- C2-Symmetric Chiral-at-Ruthenium Catalyst for Highly Efficient Enantioselective Intramolecular C(sp3)-H Amidation

A new class of chiral ruthenium catalysts is introduced in which ruthenium is cyclometalated by two 7-methyl-1,7-phenanthrolinium heterocycles, resulting in chelating pyridylidene remote N-heterocyclic carbene ligands (rNHCs). The overall chirality results from a stereogenic metal center featuring either a or Δabsolute configuration. This work features the importance of the relative metal-centered stereochemistry. Only the non-C2-symmetric chiral-at-ruthenium complexes display unprecedented catalytic activity for the intramolecular C(sp3)-H amidation of 1,4,2-dioxazol-5-ones to provide chiral -lactams with up to 99:1 er and catalyst loadings down to 0.005 mol % (up to 11 ?200 TON), while the C2-symmetric diastereomer favors an undesired Curtius-type rearrangement. DFT calculations elucidate the origins of the superior C-H amidation reactivity displayed by the non-C2-symmetric catalysts compared to related C2-symmetric counterparts.

Preparation method of carboxylic acid compound

The invention provides a preparation method of a carboxylic acid compound. The preparation method comprises the following step of taking a lactone component to react with hydrogen in the presence of a compound catalyst to obtain the carboxylic acid compound. The compound catalyst comprises a hydrogenation catalyst and Lewis acid. In the presence of the compound catalyst comprising the hydrogenation catalyst and the Lewis acid, the lactone component is subjected to hydrogenation ring-opening reaction to obtain the carboxylic acid compound. The preparation method has the advantages of moderate reaction conditions and high yield; compared with a traditional method, less byproducts are generated, green and chemical requirements are met and the industrial value is better.