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1643354-27-1

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  • SAGECHEM/2,2'-[[[4-(3-Oxo-4-morpholinyl)phenyl]imino]bis[(2R)-2-hydroxy-3,1-propanediyl]]bis[1H-isoindole-1,3(2H)-dione]

    Cas No: 1643354-27-1

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1643354-27-1 Usage

Description

2,2'-((2R,2'R)-((4-(3-oxomorpholino)phenyl)azadiyl)bis(2-hydroxypropane-3,1-diyl))bis(isoindoline-1,3-dione) is a complex organic compound with a unique chemical structure. It is characterized by its azadiyl and morpholino groups, as well as its isoindoline-1,3-dione moieties. 2,2'-((2R,2'R)-((4-(3-oxomorpholino)phenyl)azadiyl)bis(2-hydroxypropane-3,1-diyl))bis(isoindoline-1,3-dione) is an impurity found in Rivaroxaban (R538000), a novel antithrombotic agent with potent and selective direct FXa inhibitory properties.

Uses

Used in Pharmaceutical Industry:
2,2'-((2R,2'R)-((4-(3-oxomorpholino)phenyl)azadiyl)bis(2-hydroxypropane-3,1-diyl))bis(isoindoline-1,3-dione) is used as an impurity in the production of Rivaroxaban (R538000), a novel antithrombotic agent. Its presence in the manufacturing process is significant due to the potential impact on the efficacy and safety of the final product. As a result, it is essential to monitor and control the levels of this impurity during the synthesis and formulation of Rivaroxaban to ensure the desired therapeutic outcomes and minimize any adverse effects.
In addition to its role as an impurity in the pharmaceutical industry, the compound may also have potential applications in other fields, such as materials science or chemical research, due to its unique chemical structure. However, further investigation and research would be required to explore these possibilities and determine the specific uses and benefits of 2,2'-((2R,2'R)-((4-(3-oxomorpholino)phenyl)azadiyl)bis(2-hydroxypropane-3,1-diyl))bis(isoindoline-1,3-dione) in these areas.

Check Digit Verification of cas no

The CAS Registry Mumber 1643354-27-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,4,3,3,5 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1643354-27:
(9*1)+(8*6)+(7*4)+(6*3)+(5*3)+(4*5)+(3*4)+(2*2)+(1*7)=161
161 % 10 = 1
So 1643354-27-1 is a valid CAS Registry Number.

1643354-27-1Downstream Products

1643354-27-1Relevant articles and documents

Preparation method of 4-(4-aminophenyl)morpholin-3-one derivative

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Paragraph 0042-0044; 0049-0050; 0052-0055, (2020/09/30)

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a 4-(4-aminophenyl)morpholin-3-one derivative. The preparation method comprises the following steps: reacting 4-(4-aminophenyl)morpholin-3-one serving as a raw material with a first reactant to obtain a first intermediate product; and in a first solvent and with the first intermediate product as a raw material, adding (S)-N-(2,3-epoxypropyl)phthalimide in batches in multiple times, and carrying out a reaction at a first temperature to obtain a target product, namely the 4-(4-aminophenyl)morpholin-3-one derivative. According to the method, the solvent is optimized, so a conversion rate is improved; the mode of feeding in batches in multiple times and a post-treatment mode (concentration, crystallization, filtration, drying and the like) are used, so the target product with high yield is obtained; and the target product is the 4-(4-aminophenyl)morpholin-3-one derivative, and the method has important significance in effectively controlling the quality of rivaroxaban.

Rivaroxaban impurities and preparing method and application thereof

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Paragraph 0056; 0057, (2017/08/28)

The invention discloses rivaroxaban impurities. The rivaroxaban impurities include the rivaroxaban impurity 6, the rivaroxaban impurity 10, the rivaroxaban impurity 11 and the rivaroxaban impurity 12; in addition, the invention discloses a preparing method and application of the rivaroxaban impurities. By means of the rivaroxaban impurities and the preparing method thereof, the basis is consolidated for rivaroxaban midbodies and raw material medicine and quality researching of compositions of the rivaroxaban impurities. The structural formula is shown in the specification.

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