1643360-03-5

Basic information

• Product Name: N-α-acetyl-2-(2-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester
• Synonyms: N-α-acetyl-2-(2-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester
• CAS NO: 1643360-03-5
• Molecular Weight: 445.441
• Mol File: 1643360-03-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-α-acetyl-2-(2-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-α-acetyl-2-(2-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester(1643360-03-5)
• EPA Substance Registry System: N-α-acetyl-2-(2-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester(1643360-03-5)

Safety Data

• Hazardous Substances Data: 1643360-03-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 36097-48-0 N^α-acetyl-L-histidine methyl ester 
• 444-29-1 2-iodo(trifluoromethyl)benzene 

Relevant articles and documents

Regiocontrolled palladium-catalyzed and copper-mediated C-H bond functionalization of protected l-histidine

We describe the controlled and regioselective transition-metal-catalyzed C-H bond arylation of protected l-histidine with aryl halides as the coupling partner. Using this approach, a large number of C-2 arylated l-histidines have been synthesized with diverse substitutions bearing electron-donating and electron-withdrawing groups, in good to excellent yields. These synthetic amino acids possessing dual hydrophobic-hydrophilic character are important synthons of bioactive peptidomimetics, which are imperative potent inhibitors of Cryptococcus neoformans. This journal is the Partner Organisations 2014.