16440-98-5

Basic information

• Product Name: 6,7-DiMethyl-2,3-dihydro-1H-inden-1-one
• Synonyms: 6,7-DiMethyl-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-6,7-diMethyl-;6,7-dimethyl-1-indanone;6,7-dimethyl-2,3-dihydroinden-1-one
• CAS NO: 16440-98-5
• Molecular Formula: C11H12O
• Molecular Weight: 160.21238
• Mol File: 16440-98-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6,7-DiMethyl-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DiMethyl-2,3-dihydro-1H-inden-1-one(16440-98-5)
• EPA Substance Registry System: 6,7-DiMethyl-2,3-dihydro-1H-inden-1-one(16440-98-5)

Safety Data

• Hazardous Substances Data: 16440-98-5(Hazardous Substances Data)

Usage

General Description

6,7-Dimethyl-2,3-dihydro-1H-inden-1-one is a chemical compound with the molecular formula C11H14O. It is a bicyclic ketone with a unique molecular structure, consisting of a seven-membered ring and a five-membered ring fused together. 6,7-DiMethyl-2,3-dihydro-1H-inden-1-one is commonly used as a flavor and fragrance ingredient, adding a sweet, floral, and slightly woody aroma to various products. It can be found in a variety of consumer goods such as perfumes, cosmetics, and scented candles. Additionally, it has potential applications in the pharmaceutical and food industries as a flavoring agent and odorant. Overall, 6,7-Dimethyl-2,3-dihydro-1H-inden-1-one plays an important role in enhancing the sensory characteristics of many commercial products.

Upstream product

• 26801-37-6 3-(3,4-dimethylphenyl)propionyl chloride 
• 25173-76-6 3-(3,4-dimethylphenyl)propionic acid 
• 112631-51-3 2-(2,3-dimethylbenzoyl)ethyl chloride 
• 112631-50-2 4-bromo-6,7-dimethyl-1-indanone 
• 5973-71-7 3,4-dimethylbenzaldehyde 
• 6966-10-5 3,4-dimethylbenzyl alcohol 
• 147219-20-3 3-(3,4-Dimethylphenyl)-propensaeure 
• 38404-42-1 methyl 3,4-dimethylbenzoate 
• 619-04-5 3,4-dimethylbenzoic acid 
• 21900-46-9 2,3-dimethylbenzoyl chloride 
• 112631-49-9 3-(2-bromo-4,5-dimethylphenyl)propionic acid 
• 50-00-0 formaldehyd 
• 108-59-8 malonic acid dimethyl ester 
• 603-79-2 2,3-dimethylbenzoic acid 

Relevant articles and documents

Rh-Catalyzed Annulation of Benzoic Acids, Formaldehyde, and Malonates via ortho-Hydroarylation to Indanones

A three-component reaction from readily available low-cost materials of benzoic acids, formaldehyde, and malonates for the preparation of indanones by rhodium catalysis is reported. The annulation is initiated by an ortho-hydroarylation of benzoic acids, and a Lewis acid is not required. The solvent has a significant influence to the reaction, and 2-substituted or nonsubstituted indanones are obtained by the change of solvent.

Aromatic Spiranes XX [1]: Syntheses of Dimethylsubstituted 2-Carboxymethyl-indan-1-ones and Benzylchlorides as Synthones for Syntheses of di- to tetramethylsubstituted Spirobiindandiones

The isomeric dimethyl methylbenzoates 5, obtained from the bromides via Grignard reactions with dimethylcarbonate, were reduced with LiAlH4 to the hydroxymethyl derivatives 6. The latter were then transformed both to the benzylchlorides 7 (with SOCl2) and to the aldehydes 8 (with pyridinium chlorochromate). Knoevenagel-Doebner reaction of 8 afforded the acrylic acids 9 which (after hydrogenation to 11) were cyclized to the desired indanones 12 with polyphosphoric acid. On the other hand, 12c and 12e were prepared from dimethyl 3-chloropropiophenone (14) by warming with sulfuric acid. After NaH-catalyzed reaction with dimethylcarbonate, the indanones 12 gave the ketoesters 15 which then could be hydrogenated to the indanes 16. All reactions proceeded with satisfactory to excellent yields (60-90%).