1644384-68-8Relevant articles and documents
Practical Continuous-Flow Trapping Metalations of Functionalized Arenes and Heteroarenes Using TMPLi in the Presence of Mg, Zn, Cu, or la Halides
Becker, Matthias R.,Knochel, Paul
supporting information, p. 12501 - 12505 (2015/10/12)
The flow metalation of various arenes and heteroarenes involving an in situ trapping with metal salts (ZnCl2. LiCl, MgCl2, CuCN. LiCl, LaCl3. LiCl) under very convenient conditions (0 ?C, 40 s) is reported. The resulting Mg, Zn, Cu, or La organic species are trapped with various electrophiles in high yields. In several cases, unusual kinetically controlled regioselectivities are obtained. All these flow metalations can be scaled up simply by extending the reaction time and without further optimization. The reaction scope of such flow metalations is considerably broader than that of the corresponding batch procedures.