1646630-19-4

Basic information

• Product Name: N¹,N¹,N⁴,N⁴-tetraethyl-2-hydroxyterephthalamide
• Synonyms: N¹,N¹,N⁴,N⁴-tetraethyl-2-hydroxyterephthalamide
• CAS NO: 1646630-19-4
• Molecular Weight: 292.378
• Mol File: 1646630-19-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N¹,N¹,N⁴,N⁴-tetraethyl-2-hydroxyterephthalamide(CAS DataBase Reference)
• NIST Chemistry Reference: N¹,N¹,N⁴,N⁴-tetraethyl-2-hydroxyterephthalamide(1646630-19-4)
• EPA Substance Registry System: N¹,N¹,N⁴,N⁴-tetraethyl-2-hydroxyterephthalamide(1646630-19-4)

Safety Data

• Hazardous Substances Data: 1646630-19-4(Hazardous Substances Data)

Upstream product

• 109-89-7 diethylamine 
• 636-94-2 2-hydroxyterephthalic acid 

Downstream Products

• 1646630-44-5 4-acetyl-N,N-diethyl-3-hydroxybenzamide 

Relevant articles and documents

Lithiation of a silyl ether: Formation of an ortho-fries hydroxyketone

A hydroxy-directed alkylation of an N,N-diethylarylamide using CIPE-assisted α-silyl carbanions (CIPE=complex-induced proximity effect) has been developed using a simple reagent combination of LDA (lithium diisopropylamide) and chlorosilane. A study of the mechanism, and the application of the procedure to an anionic Snieckus-Fries rearrangement for a highly efficient synthesis of the potent phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, are reported.