1647-74-1

Basic information

• Product Name: 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide
• Synonyms: 2-(Bromoacetylamino)-5-bromo-2'-fluorobenzophenone;2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide
• CAS NO: 1647-74-1
• Molecular Formula: C₁₅H₁₀Br₂FNO₂
• Molecular Weight: 415.05
• Mol File: 1647-74-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 139-140 °C
• Boiling Point: 585.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.772±0.06 g/cm3(Predicted)
• PKA: 10.92±0.70(Predicted)
• CAS DataBase Reference: 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide(1647-74-1)
• EPA Substance Registry System: 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide(1647-74-1)

Safety Data

• Hazardous Substances Data: 1647-74-1(Hazardous Substances Data)

Usage

Description

2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide is a chemical compound that serves as an intermediate in the synthesis of various pharmaceutical agents. It is characterized by its unique molecular structure, which includes bromo and fluoro substituents, as well as a benzoyl group attached to the phenyl ring. 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide plays a crucial role in the development of sedative and hypnotic medications.

Uses

Used in Pharmaceutical Industry:
2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide is used as an intermediate in the synthesis of Haloxazolam (H104000), a sleep-inducing agent. It is structurally related to other sedative and hypnotic drugs such as Oxazolam and Cloxazolam (C587475). The compound contributes to the development of medications that help alleviate insomnia and promote relaxation.
As a sedative and hypnotic agent, 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide is used for its calming effects on the central nervous system. It is particularly useful in treating conditions such as anxiety and insomnia, where a controlled substance is required to induce sleep and reduce anxiety levels.
Furthermore, 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide is also used as a controlled substance (depressant) due to its potential for abuse and dependence. Its use is regulated to ensure that it is prescribed and administered responsibly, minimizing the risk of misuse and addiction.

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 74189-16-5 2-amino-5-bromobenzoic acid hydrochloride 
• 304854-54-4 2-amino-5-bromo-N-methoxy-N-methyl-benzamide 
• 1479-58-9 5-bromo-2'-fluoro-2-aminobenzophenone 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 62659-65-8 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one 
• 10329-38-1 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide 
• 2647-50-9 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one 

Relevant articles and documents

Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin

High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.

Carboxamide GABAa ALPHA2 Modulators

The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.