16485-10-2 Usage
Description
Panthenol, also known as pantothenol, is the alcohol analog of pantothenic acid (vitamin B5) and is considered a provitamin of B5. It is a viscous transparent liquid at room temperature and is quickly oxidized to pantothenic acid in organisms. Panthenol plays a crucial role in the formation of acetyl-coenzyme A, which is essential for various metabolic processes, including the production of energy, synthesis of fatty acids, and detoxification of foreign substances.
Uses
Used in Pharmaceutical and Cosmetic Products:
Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products. It is valued for its moisturizing properties, anti-inflammatory effects, and ability to soothe irritated and sensitive skin.
Used in Dermatological Applications:
Panthenol is used as a topical treatment for dermatological conditions, such as minor irritations and skin burns. It promotes increased fibroblast proliferation, accelerated re-epithelialization in wound healing, and acts as a topical protectant, moisturizer, and anti-inflammatory agent.
Used in Skin and Hair Care Applications:
Panthenol is used in skin and hair care applications for its moisturizing properties and humectant character, which helps hold water and provide a moisturizing effect. It enhances skin suppleness and is known to improve the resistance of hair to mechanical stress.
Used in Antimicrobial Applications:
Panthenol has been shown to have antimicrobial properties, making it useful in the development of new treatments for various infections.
Used as a Radioprotectant:
Panthenol is used as a radioprotectant, helping to protect the body from the harmful effects of radiation.
Used as an Antimalarial:
Panthenol has been studied for its potential use as an antimalarial agent, offering a new approach to treating this disease.
Used in Strengthening and Treatment of Hair:
Panthenol is used in the strengthening and treatment of hair, providing benefits such as improved hair health and resistance to breakage.
Mechanism of action
Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. The final step in the synthesis of
acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline. Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such
maintains the normal functions of the intestine. Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus.
Panthenol is well absorbed into the skin and quickly converted into Pantothenic acid by oxidation. Pantothenic acid is distributed into the cells and is converted to Acetyl Coenzyme-A (Acetyl CoA)
in the cells of the epidermis. Human being require Vitamin B5 to synthesize Acetyl CoA which is an essential mediator to many biochemical reactions that sustain life (maintenance and repair of all
cells) and which breaks down fats, carbohydrates and proteins for carbon dioxide, water, and energy generation. Furthermore, it synthesis fatty acids and sphingolipids, for stratum corneum lipid
layers and cell membrane integrity & fluidity.
Side effects
Panthenol is generally well tolerated. In rare cases, skin irritation and contact allergies have been reported. Generally, topical panthenol formulations were well tolerated with minimal risk of skin irritation or sensitization.
Flammability and Explosibility
Nonflammable
Check Digit Verification of cas no
The CAS Registry Mumber 16485-10-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,4,8 and 5 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 16485-10:
(7*1)+(6*6)+(5*4)+(4*8)+(3*5)+(2*1)+(1*0)=112
112 % 10 = 2
So 16485-10-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)
16485-10-2Relevant articles and documents
Method For the Production of a Keratin-Binding Effector Molecule
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, (2009/04/24)
The invention relates to a method of producing keratin-binding effector molecules, and to intermediates and end-products of the method according to the invention and to the use of the keratin-binding effector molecules produced according to the invention in dermocosmetics. In addition, the invention relates to a method of applying dermocosmetically active ingredients to skin and/or hair and to a method of increasing the residence time of an active ingredient on skin and hair.
