164931-80-0

Basic information

• Product Name: Propanedioic acid, [(1S)-3-oxo-1,3-diphenylpropyl]-, dimethyl ester
• CAS NO: 164931-80-0
• Molecular Formula: C20H20O5
• Molecular Weight: 340.376
• Mol File: 164931-80-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [(1S)-3-oxo-1,3-diphenylpropyl]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [(1S)-3-oxo-1,3-diphenylpropyl]-, dimethyl ester(164931-80-0)
• EPA Substance Registry System: Propanedioic acid, [(1S)-3-oxo-1,3-diphenylpropyl]-, dimethyl ester(164931-80-0)

Safety Data

• Hazardous Substances Data: 164931-80-0(Hazardous Substances Data)

Upstream product

• 94-41-7 benzalacetophenone 
• 108-59-8 malonic acid dimethyl ester 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 5292-53-5 diethyl benzalmalonate 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 98-86-2 acetophenone 
• 1214-54-6 5-benzylidene Meldrum's acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 95071-02-6 dimethyl 2-[(E)-(S)-1,3-diphenylallyl]-malonate 

Downstream Products

• 182360-64-1 2-((S)-2-Chlorocarbonyl-1-phenyl-ethyl)-malonic acid dimethyl ester 
• 182360-62-9 (S)-2-phenyl-1,1,3-propanetricarboxylic acid 1,1-dimethyl ester 
• 359876-02-1 dimethyl (S)-(-)-4-oxo-2-phenyl-1,1-pentanedicarboxylate 
• 108056-64-0 (S)-5-oxo-3-phenylhexanoic acid 
• 108056-65-1 methyl (S)-(-)-5-oxo-3-phenylhexanoate 

Relevant articles and documents

Enantioselective Michael addition of malonic esters to benzalacetophenone by using chiral phase transfer catalysts derived from proline-mandelic acid/tartaric acid

Abstract: Herein, we have explored the enantioselective Michael addition of various malonate esters to benzalacetophenone by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid under mild phase t

Enantioselective Michael Addition of Malonates to Chalcone Derivatives Catalyzed by Dipeptide-derived Multifunctional Phosphonium Salts

Highly enantioselective Michael addition of malonates to enones catalyzed by dipeptide-derived multifunctional phosphonium salts has been developed. The newly established catalytic system was characterized with its wide substrate scope featured with aliphatic aldehyde-derived enones and substituted malonates. The gram scale-up synthesis of adducts can also be successfully achieved under optimal conditions with both excellent yield and enantioselectivity.

CATALYST AND REACTION PROCESS

Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time. Specifically disclosed is a catalyst which is composed of MX2 /sup