16503-95-0

Basic information

• Product Name: 7,8-dimethoxyisoquinoline
• Synonyms: iso-Backebergine
• CAS NO: 16503-95-0
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.2105
• Mol File: 16503-95-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 319.9°C at 760 mmHg
• Flash Point: 117.2°C
• Density: 1.148g/cm³
• Vapor Pressure: 0.000614mmHg at 25°C
• Refractive Index: 1.589
• PKA: 5.72±0.26(Predicted)
• CAS DataBase Reference: 7,8-dimethoxyisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-dimethoxyisoquinoline(16503-95-0)
• EPA Substance Registry System: 7,8-dimethoxyisoquinoline(16503-95-0)

Safety Data

• Hazardous Substances Data: 16503-95-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 27, p. 1253, 1971 DOI: 10.1016/S0040-4020(01)90874-9

Upstream product

• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 191112-91-1 N-(2,3-Dimethoxy-benzyl)-N-(2,2-dimethoxy-ethyl)-C-phenyl-methanesulfonamide 
• 5653-67-8 2,3-dimethoxybenzyl alcohol 
• 16503-92-7 (+/-)dimethoxy-7,8 hydroxy-4 tetrahydro-1,2,3,4 isoquinoleine 
• 191112-97-7 7,8-Dimethoxy-2-phenylmethanesulfonyl-1,2-dihydro-isoquinoline 
• 54879-78-6 2,3-dimethoxybenzylaminoacetaldehyde dimethylacetal 

Downstream Products

• 1028301-81-6 2-benzoyl-1-(3,4-dimethoxy-benzyl)-7,8-dimethoxy-1,2-dihydro-isoquinoline-1-carbonitrile 
• 1028301-15-6 2-benzoyl-7,8-dimethoxy-1-naphthalen-2-ylmethyl-1,2-dihydro-isoquinoline-1-carbonitrile 
• 917201-23-1 1-(3,4-dimethoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline 
• 20122-48-9 1-(3,4-dimethoxybenzyl)-7,8-dimethoxy-isoquinoline 
• 21968-49-0 2-benzoyl-1-cyano-7,8-dimethoxy-1,2-dihydroisoquinoline 

Relevant articles and documents

Gastric-mucous membrane protection activity of coptisine derivatives

Coptisine and 8-oxocoptisine were isolated as principles of the gastric-mucous membrane protection from Coptidis rhizoma. The two compounds showed stronger activity than cimetidine and sucralfate. We prepared several derivatives having a partial structure of coptisine from commercially available starting materials. The compounds obtained were tested for gastric-mucous membrane protective activity and a correlation between activity and structure was studied. Our results suggest that the partial charge of the catechol skeleton is related to activity.