1652-64-8

Basic information

• Product Name: 1,1,3-Propanetricarboxylic acid, 1-(acetylamino)-3-fluoro-, triethyl ester
• CAS NO: 1652-64-8
• Molecular Formula: C14H22FNO7
• Molecular Weight: 335.33
• Mol File: 1652-64-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,1,3-Propanetricarboxylic acid, 1-(acetylamino)-3-fluoro-, triethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,3-Propanetricarboxylic acid, 1-(acetylamino)-3-fluoro-, triethyl ester(1652-64-8)
• EPA Substance Registry System: 1,1,3-Propanetricarboxylic acid, 1-(acetylamino)-3-fluoro-, triethyl ester(1652-64-8)

Safety Data

• Hazardous Substances Data: 1652-64-8(Hazardous Substances Data)

Usage

Functional groups

Acetylamino (COCH3NH-)
Fluoro (F-)
Triethyl ester (OC2H5)3

Chemical structure

A propanetricarboxylic acid derivative with an acetylamino group at the 1-position, a fluoro group at the 3-position, and three ethoxy groups attached to the carboxylic acid groups.

Applications

Building block in the synthesis of pharmaceuticals
Building block in the synthesis of other organic compounds

Potential uses

Development of drugs for various therapeutic purposes
Chemical research and development

Importance

Structural properties that allow for a wide range of potential uses
Significance in the field of medicinal chemistry and drug discovery

Upstream product

• 760-80-5 ethyl 2-fluoroacrylate 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 

Downstream Products

• 95772-55-7 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-fluoro-pentanedioic acid diisopropyl ester 
• 95755-20-7 N-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-4-fluoro-glutamic acid 
• 95755-24-1 2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-fluoro-pentanedioic acid diisopropyl ester 
• 95755-25-2 2-Fluoro-4-(4-methylamino-benzoylamino)-pentanedioic acid diisopropyl ester 
• 2708-77-2 D,L-erythro,threo-4-fluoroglutamic acid 

Relevant articles and documents

Chemistry of 4-fluoroglutamic acid. Part 1. A critical survey of its syntheses: an attempt to optimize reaction conditions for large-scale preparation

Synthetic methods for the preparation of 4-fluoroglutamic acid (1) are reviewed.The utility of every method for routine laboratory work is evaluated with respect to the accessibility of starting materials and reagents, the overall yields and also from the viewpoint of safety.Optimum reaction conditions are given for the selected pathway, suitable for large-scale synthesis.

SYNTHESIS OF 2-FLUOROPROPENOIC ACID DERIVATIVES

A method is described for the synthesis of 2-fluoropropenoic acid esters, amides, and nitrile from the corresponding derivatives of 2-fluoro-3-(4-toluenesulfonyloxy)propanoic acid by heating with potassium phtalimide in vacuo.The free acid Ia and its chloride have also been synthetized.The reactivity of esters and nitrile of acid Ia has been verified by the Michael addition of diethyl acetamidomalonate to these compounds.