165258-70-8 Usage
General Description
2-AMINO-4-DIMETHYLAMINO-6-FLUOROPYRIMIDINE, also known as Leflunomide, is a chemical compound that is used as an immunomodulatory and anti-inflammatory medication. It is primarily used to treat rheumatoid arthritis by suppressing the immune system and reducing inflammation in the joints. Leflunomide works by inhibiting dihydroorotate dehydrogenase, an enzyme that is involved in the production of DNA and RNA in rapidly dividing cells such as those found in the immune system. This medication is available in various forms including tablets and can be used alone or in combination with other medications to manage rheumatoid arthritis. It has also shown promise in the treatment of other autoimmune diseases and certain types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 165258-70-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,2,5 and 8 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 165258-70:
(8*1)+(7*6)+(6*5)+(5*2)+(4*5)+(3*8)+(2*7)+(1*0)=148
148 % 10 = 8
So 165258-70-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H9FN4/c1-11(2)5-3-4(7)9-6(8)10-5/h3H,1-2H3,(H2,8,9,10)
165258-70-8Relevant articles and documents
Synthesis and Properties of 2,4-Disubstituted 6-Fluoropyrimidines
Popova,Studentsov
, p. 1376 - 1381 (2007/10/03)
Reaction of 2,4,6-trifluoropyrimidine and 2- and 4-aminodifluoropyrimidines with various amines in DMF is studied. As a result, a series of new 2,4-diamino-substituted 6-fluoropyrimidines with similar or different amino substituents are synthesized.
