16561-29-8 Usage
Description
Phorbol 12-Myristate 13-Acetate, also known as 4β-Phorbol 12-Myristate 13-Acetate, is a white to off-white crystalline compound with the chemical formula C36H66O6. It is a potent activator of protein kinase C (PKC) and certain pyruvate kinases, playing a significant role in various cellular processes. Due to its potent activity, it is considered a skin irritant and should be handled with caution.
Uses
Used in Biochemical Research:
Phorbol 12-Myristate 13-Acetate is used as a research tool for activating protein kinase C (PKC) and certain pyruvate kinases. This activation helps in studying the role of these enzymes in various cellular processes and their potential involvement in diseases.
Used in Cellular Signaling Studies:
As a potent activator of PKC, Phorbol 12-Myristate 13-Acetate is used in cellular signaling studies to understand the mechanisms of signal transduction and the regulation of cellular functions.
Used in PKC-Dependent and PKC-Independent Effects Research:
Phorbol 12-Myristate 13-Acetate may display PKC-independent effects in various cell types, making it a valuable compound for investigating the diverse roles of PKC in cellular processes.
Used in Drug Development:
Due to its ability to activate protein kinase C, Phorbol 12-Myristate 13-Acetate can be used in the development of drugs targeting PKC-related pathways, potentially leading to the discovery of new therapeutic agents for various diseases.
Reactivity Profile
PHORBOL 12-MYRISTATE 13-ACETATE is sensitive to acids and alkalis. .
Fire Hazard
Flash point data for PHORBOL 12-MYRISTATE 13-ACETATE are not available; however, PHORBOL 12-MYRISTATE 13-ACETATE is probably combustible.
Biological Activity
Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a K i value of 2.6 nM as measured by displacement of [ 3 H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.
Biochem/physiol Actions
Cell permeable: yes
References
1) Saraiva et al. (2004), Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay; Eur. J. Pharmacol., 491 101
2) Doerner et al. (1990), Protein kinase C-dependent and independent effects of phorbol esters on hippocampal calcium channel current; J. Neurosci., 10 1699
3) Merck Index 14:7332
Check Digit Verification of cas no
The CAS Registry Mumber 16561-29-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,6 and 1 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 16561-29:
(7*1)+(6*6)+(5*5)+(4*6)+(3*1)+(2*2)+(1*9)=108
108 % 10 = 8
So 16561-29-8 is a valid CAS Registry Number.
InChI:InChI=1/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24?,27-,28?,30+,32+,34+,35+,36+/m0/s1
