165669-24-9

Basic information

• Product Name: 4-cyano-N-(1H-indole-7-yl)benzenesulfonamide
• Synonyms: 4-cyano-N-(1H-indole-7-yl)benzenesulfonamide
• CAS NO: 165669-24-9
• Molecular Weight: 297.337
• Mol File: 165669-24-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-cyano-N-(1H-indole-7-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyano-N-(1H-indole-7-yl)benzenesulfonamide(165669-24-9)
• EPA Substance Registry System: 4-cyano-N-(1H-indole-7-yl)benzenesulfonamide(165669-24-9)

Safety Data

• Hazardous Substances Data: 165669-24-9(Hazardous Substances Data)

Upstream product

• 6960-42-5 7-nitro-1H-indole 
• 81524-76-7 7-azido-1H-indole 
• 577-19-5 2-nitrophenyl bromide 
• 51417-51-7 7-bromo-1H-indole 
• 5192-04-1 7-aminoindole 
• 49584-26-1 p-cyanobenzenesulfonyl chloride 

Downstream Products

• 165668-32-6 N-(3-Chloro-1H-indole-7-yl)-4-cyanobenzenesulfonamide 

Relevant articles and documents

A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template. (C) 2000 Elsevier Science Ltd. All rights reserved.

Heterobicyclic sulfonamide and sulfonic ester derivatives

Novel heterobicyclic sulfonamide and sulfonic ester derivatives represented by the following general formula(I), which exhibit an antitumor activity and are lowly toxic, and processes for the preparation thereof. A sulfonamide derivative and a sulfonic ester derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof: STR1 wherein A represents a monocyclic or bicyclic aromatic ring which may be substituted; B represents a six-membered unsaturated hydrocarbon ring or a six-membered unsaturated heterocycle containing one nitrogen atom, each of which may be substituted; C represents a five-membered heterocycle containing one or two nitrogen atoms which may be substituted; W represents a single bond or a group represented by formula --CH=CH--; X represents a group represented by formula --N(R1)-- or oxygen; Y represents carbon or nitrogen; Z represents a group represented by formula --N(R2)-- or nitrogen; and R1 and R2 may be the same or different from each other and each represent hydrogen or lower alkyl.