165682-91-7Relevant articles and documents
Synthesis and cellular uptake of p-[123I]-phenyl-amino-thiazole (123I-PAT) as a potential agent for targeting tubulin polymerization in tumors
Wang, Da-Ming,Kuo, Jia-Wei,Kuo, Wei-Ti,Hsu, Cheng-Fang,Wang, Mei-Hui,Chang, Yu,Lin, Wuu-Jyh,Wang, Jen-Tsung
, p. 132 - 135 (2014)
The phenyl-amino-thiazole (PAT) templates of methoxylbenzoyl-aryl-thiazole are potent agents against cancer by inhibiting tubulin polymerization in the nanomolar range. Herein, a radioiodinated PAT, [123I]-PAT 1, was prepared via a tributylstannyl precursor and [123I]iodide through electrophilic aromatic radioiodination. Radiolabelling of [123I]-PAT 1 was achieved in less than 15 min, with a radiochemical purity of over 99%. The accumulated radioactivity in tumor cellular uptake experiments suggested that [123I]-PAT could serve as a potential radioprobe for targeting tumor cells. Copyright
Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4
Cheng, Xinlai,Yoshida, Hiroki,Raoofi, Dena,Saleh, Sawsan,Alborzinia, Hamed,Wenke, Frank,G?hring, Axel,Reuter, Stefanie,Mah, Nancy,Fuchs, Heiko,Andrade-Navarro, Miguel A.,Adjaye, James,Gul, Sheraz,Utikal, Jochen,Mrowka, Ralf,W?lfl, Stefan
, p. 5742 - 5750 (2015/08/24)
The octamer-binding transcription factor 4 (Oct3/4) is a master gene in the transcriptional regulatory network of pluripotent cells. Repression of Oct3/4 in embryonic stem cells (ESCs) is associated with cell differentiation and loss of pluripotency, wher
