165736-07-2

Basic information

• Product Name: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE
• Synonyms: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE;(2,4-Dimethylthiazol-5-yl)methanamine;1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine(SALTDATA: 2HCl);C-(2,4-DiMethyl-thiazol-5-yl)-MethylaMine;(2,4-DiMethyl-thiazol-5-yl)MethylaMine;(2,4-diMethyl-1,3-thiazol-5-yl)MethanaMine;5-ThiazoleMethanaMine,2,4-diMethyl-;2,4-Dimethyl-5-thiazolemethanamine
• CAS NO: 165736-07-2
• Molecular Formula: C₆H₁₀N₂S
• Molecular Weight: 142.22
• Mol File: 165736-07-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 243.34 °C at 760 mmHg
• Flash Point: 100.969 °C
• Appearance: /
• Density: 1.141 g/cm³
• Vapor Pressure: 0.0323mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: 2-8°C
• PKA: 8.31±0.29(Predicted)
• CAS DataBase Reference: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE(165736-07-2)
• EPA Substance Registry System: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE(165736-07-2)

Safety Data

• Hazardous Substances Data: 165736-07-2(Hazardous Substances Data)

Usage

General Description

1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine, also known as DMTA, is a chemical compound with a thiazole structure that contains a primary amine functional group. 1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine is commonly used in pharmaceutical and chemical research as a building block for the synthesis of various bioactive molecules and agrochemicals. It has also been studied for its potential antimicrobial and antiviral properties. DMTA has a molecular formula of C6H10N2S and a molecular weight of 142.23 g/mol. It is a colorless to pale yellow liquid at room temperature and should be handled with care due to its toxicity and potential health hazards.

InChI:InChI=1/C6H10N2S/c1-4-6(3-7)9-5(2)8-4/h3,7H2,1-2H3

Upstream product

• 7210-77-7 ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate 
• 50382-32-6 (2,4-dimethyl-1,3-thiazol-5-yl)methanol 
• 95453-54-6 2,4-dimethyl-1,3-thiazole-5-carbaldehyde 

Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells

Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.