16596-01-3

Basic information

• Product Name: N,N'-Di-o-tolylformamidine
• Synonyms: N-(2-Methylphenyl)[(2-methylanilino)methaneimine];N,N'-Di(o-tolyl)formamidine;N,N'-Di-o-tolylformamidine;N-[(o-Tolylimino)methyl]-o-tolylamine
• CAS NO: 16596-01-3
• Molecular Formula: C₁₅H₁₆N₂
• Molecular Weight: 224.3009
• Mol File: 16596-01-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 356.7°Cat760mmHg
• Flash Point: 169.5°C
• Appearance: /
• Density: 0.99g/cm³
• CAS DataBase Reference: N,N'-Di-o-tolylformamidine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-Di-o-tolylformamidine(16596-01-3)
• EPA Substance Registry System: N,N'-Di-o-tolylformamidine(16596-01-3)

Safety Data

• Hazardous Substances Data: 16596-01-3(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 71-43-2 benzene 
• 94-69-9 2'-methylformanilide 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 
• 64-19-7 acetic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 1215-57-2 N,N'-bis(o-methylphenyl)carbodiimide 
• 76085-56-8 N-(dichloromethyl)methanimidamide hydrochloride 
• 10468-64-1 o-tolyl isocyanide 
• 636-21-5 o-toluidine hydrochloride 
• 141-53-7 sodium formate 
• 107866-06-8 N-o-tolyl-formimidic acid methyl ester 
• 26060-47-9 2-methylphenylthioformamide 

Downstream Products

• 106421-79-8 N-phenyl-N'-o-tolyl-formamidine 
• 4479-33-8 tris-(4-amino-3-methyl-phenyl)-methane 
• 64190-02-9 Mo₂(HC(NC₆H₄CH₃)2)4 
• 292642-60-5 [Cr₂(N,N'-bis(o-tolyl)formamidinate)4] 
• 1337917-63-1 1,3-bis(2-methylphenyl)-3,4,5,6,7,8-hexahydro-1,3-diazocin-1-ium bromide 
• 1338549-90-8 C₅H₉N₂(C₆H₄CH₃)2⁽¹⁺⁾*I^(1-)=(C₅H₉N₂(C₆H₄CH₃)2)I 
• 1309583-10-5 1,3-bis(2-methylphenyl)-4,5-dihydro-1H-imidazolinium trifluoromethanesulfonate 
• 1298123-88-2 N-hydroxy-N,N'-di(ortho-tolyl)formamidine 
• 1262732-28-4 C₄H₇N₂(C₆H₄CH₃)2⁽¹⁺⁾*Br^(1-)=(C₄H₇N₂(C₆H₄CH₃)2)Br 
• 1207893-58-0 1,3-bis(2-methylphenyl)-4,5,6,7-tetrahydro-3H-[1,3]diazepin-1-ium tetrafluoroborate 
• 94-69-9 2'-methylformanilide 
• 41996-50-3 2-methylphenylamino-(1,3-dioxo-2,3-dihydro-1H-inden-2-ylidene)ethanenitrile 
• 73187-61-8 3,5,6-trichloro-2-(2-methylphenylamino)-1,4-benzoquinone 
• 110571-63-6 4-isobutyl-3,5-dimethyl-2-[2-(2-methyl-anilino)-vinyl]-oxazolium; iodide 

Relevant articles and documents

Ionic liquid-functionalized mesoporous silica nanoparticles ([pmim]FeCl4/MSNs): Efficient nanocatalyst for solvent-free synthesis of N,N′-diaryl-substituted formamidines

We report the synthesis of ionic liquid-functionalized mesoporous silica nanoparticles ([pmim]FeCl4/MSNs) via a method of post-grafting on parent MSNs. This hybrid material was characterized using scanning and transmission electron microscopies, energy-dispersive X-ray spectroscopy, nitrogen adsorption–desorption analysis, Fourier transform infrared spectroscopy, powder X-ray diffraction and thermal analyses. The material was utilized as an efficient heterogeneous catalyst for the synthesis of N,N′-diaryl-substituted formamidines through the reaction of triethyl orthoformate with arylamines under solvent-free conditions. The catalyst was recovered easily and reused several times without significant loss of its catalytic activity.

Ultrasound promoted expeditious, catalyst-free and solvent-free approach for the synthesis of N,N′-diarylsubstituted formamidines at room temperature

An effortless and efficient protocol was developed for the synthesis of N,N′-diarylsubstituted formamidines under environment-friendly conditions. Ultrasonic energy was employed to obtain the desired products in excellent yields with high purity under solvent-free and catalyst-free conditions. Products were purified by the crystallization technique to avoid excess utilization of organic solvents.

Biomimetic approach for the synthesis of N,N′-diarylsubstituted formamidines catalyzed by β-cyclodextrin in water

An environmentally benign and highly efficient biomimetic approach for the synthesis of N,N′-diarylsubstituted formamidines in water catalyzed β-cyclodextrin is described under neutral condition with quantitative yields of products. β-Cyclodextrin has bee