166176-45-0 Usage
General Description
6-Chloro-imidazo[1,2-b]pyridazin-3-amine is a chemical compound with the molecular formula C7H5ClN4. As indicated by its name, it contains chlorine, nitrogen, hydrogen, and carbon atoms. 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZIN-3-AMINE is classified under the chemical category of organochlorines, which includes substances containing carbon-chlorine bonds. It also falls under pyridazines and amines, signifying the presence of the nitro group (-NH2) in the compound. This chemical is primarily used in research and scientific study, with specific applications not readily available because of its specialized nature. Its physical characteristics, toxicity or environmental effects are not extensively documented, indicating the need for further study and understanding of this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 166176-45-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,1,7 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 166176-45:
(8*1)+(7*6)+(6*6)+(5*1)+(4*7)+(3*6)+(2*4)+(1*5)=150
150 % 10 = 0
So 166176-45-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H5ClN4/c7-4-1-2-6-9-3-5(8)11(6)10-4/h1-3H,8H2
166176-45-0Relevant articles and documents
Studies on Anti-MRSA parenteral cephalosporins I. Synthesis and antibacterial activity of 7
Ishikawa,Iizawa,Okonogi,Miyake
, p. 1053 - 1070 (2007/10/03)
In order to improve the antibacterial activity of cefozopran (CZOP) against methicillin-resistant Staphylococcus aureus (MRSA), we initiated chemical modification to introduce a 2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-hydroxyimino acetyl group at the C-7 position and a 3- or 6-substituted imidazo[1,2-b]pyridazinium or 5-substituted imidazo[1,2-a]pyridinium group at the C-3' position. Although this approach successfully enhanced the anti-MRSA activity of CZOP two to eight times, a slight decrease in the activity against Gram-negative bacteria including Pseudomonas aeruginosa was involved. Among the novel derivatives, 3-(6-aminoimidazo [1,2-b]pyridazinium-1-yl) methyl-7β-[2-(5-amino -1,2,4-thiadiazol-3-yl) -2(Z)-hydroxyiminoacetamidol]-3-cephem-4-carboxylate (44a) showed an excellent balance of activity against MRSA and Gram-negative bacteria.
