16619-60-6

Basic information

• Product Name: 3,5-DIPHENYL-4,5-DIHYDRO-1H-PYRAZOLE
• Synonyms: 3,5-DIPHENYL-4,5-DIHYDRO-1H-PYRAZOLE
• CAS NO: 16619-60-6
• Molecular Formula: C₁₅H₁₄N₂
• Molecular Weight: 222.29
• Mol File: 16619-60-6.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 368.7°Cat760mmHg
• Flash Point: 176.8°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 1.25E-05mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 3,5-DIPHENYL-4,5-DIHYDRO-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIPHENYL-4,5-DIHYDRO-1H-PYRAZOLE(16619-60-6)
• EPA Substance Registry System: 3,5-DIPHENYL-4,5-DIHYDRO-1H-PYRAZOLE(16619-60-6)

Safety Data

• Hazardous Substances Data: 16619-60-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H14N2/c1-3-7-12(8-4-1)14-11-15(17-16-14)13-9-5-2-6-10-13/h1-10,14,16H,11H2

Upstream product

• 94-41-7 benzalacetophenone 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 180847-73-8 1,3-Dichloro-1,3-diphenylpropane 
• 1817-49-8 1,3-diphenyl-1-propyn-3-ol 

Downstream Products

• 30693-34-6 1-acetyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 92133-95-4 1-benzyl-3,5-diphenyl-1H-pyrazole 
• 1138-48-3 cis-1,2-diphenylcyclopropane 
• 1138-47-2 trans-1,2-diphenylcyclopropane 
• 1403750-40-2 (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone 
• 1403750-19-5 (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone 
• 1158801-53-6 N-(4-bromophenyl)-3,5-diphenyl-1H-pyrazoline-1-carbothioamide 
• 1158801-49-0 N-(4-nitrophenyl)-3,5-diphenyl-1H-pyrazoline-1-carbothioamide 
• 37865-25-1 N,3,5-triphenyl-pyrazoline-1-carbothioamide 
• 89969-64-2 1-(2,3-dimethoxybenzyl)-3,5-diphenyl-2-phenylthiocarbamoylpyrazolidine 
• 89969-66-4 1-(α-cyano-2,3-dimethoxybenzyl)-3,5-diphenyl-2-pyrazoline 

Relevant articles and documents

Synthesis of new pyrazoline-nucleoside analogue derivatives

In this work, a synthesis of pyrazoline nucleosides analogues is presented, using the stereospecific sodium salt glycosylation procedure. In the first step, chalcones were prepared using Claisen Schmidt reaction by reacting benzaldehyde with enolizable ketones in ethanolic NaOH solutions. Next, these chalcones were immediately reacted with hydrazine hydrochloridein the presence of dry methanol to obtain the corresponding 2-pyrazolines. Finally, the coupling of the pyrazolines with 1-chloro-arabinofuranose leads to different β-nucleosides as the major product (13-17) in good yields. The structures of these derivatives were characterized by infrared and 1HNMR spectroscopy and mass spectrometry.

A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe

In current work, a class of novel 4,5-dihydro-1H-pyrazole-1-carboxylate derivatives (E01-E28) were designed, synthesized and evaluated. Among them, the most potent compound E24 exhibited comparable activity against a panel of cancer cells (GI50

Nano-TiO2: An efficient and reusable catalyst for the synthesis of 1,3,5-substituted pyrazoles

(Formula presented) A Nano-TiO2 is an efficient catalysis for the synthesis of 1,3,5-substituted pyrazoles via condensation of 1,3- diketones and hydrazines. Simple procedure, mild heating, solvent free, high yielding, and easy workup are some advantages of this protocol. The catalyst can be recovered easily and reused many times without significant loss in catalytic activity and selectivity.