1663-47-4Relevant articles and documents
-
Katakai,Oya
, p. 180,182 (1974)
-
Using hydrogen-bonding interactions to control the peptide secondary structures and miscibility behavior of poly(l -glutamate)s with phenolic resin
Kuo, Shiao-Wei,Chen, Chi-Jen
, p. 7315 - 7326 (2011)
We synthesized three low-molecular-weight poly(glutamate)s-poly(γ- methyl l-glutamate) (PMLG), poly(γ-ethyl l-glutamate) (PELG), and poly(γ-benzyl l-glutamate) (PBLG)-through living ring-opening polymerization of their α-amino acid-N-carboxyanhydride derivatives and then blended them with phenolic resin to control the secondary structures of these polypeptides. Each of the three binary blends exhibited a single glass transition temperature (differential scanning calorimetry) and a single-exponential decay of proton spin-lattice relaxation times in the rotating frame [T1ρH; solid state nuclear magnetic resonance (NMR) spectroscopy], characteristic of a miscible system. The strength of the interassociative interactions depended on the nature of the hydrogen bond acceptor groups, increasing in the order phenolic/PELG > phenolic/PMLG > phenolic/PBLG, as evidenced through analyses using Fourier transform infrared (FTIR) spectroscopy and the Painter-Coleman association model. The fractions of α-helical conformations (measured using FTIR and solid-state NMR spectroscopy) of PMLG and PELG decreased initially upon increasing the phenolic content but increased thereafter; in contrast, the fraction of α-helical conformations of PBLG increased continuously upon increasing the phenolic contents. Using variable-temperature infrared spectroscopy to investigate the changes in the conformations of the secondary structures of the peptide segments in these three binary blends, we found that the α-helical conformation in these three blend systems correlated strongly with the rigidity of side-chain groups, the strength of the intermolecular hydrogen bonding with the phenolic resin, the compositions of phenolic resin, and the temperature. More interestingly, the content of α-helical conformations of the polypeptides in these phenolic/PBLG blends increased upon increasing the temperature.
PROCESS FOR THE PREPARATION OF N-CARBOXYANHYDRIDES
-
Page/Page column 8, (2008/06/13)
The invention relates to a process for the preparation of N-carboxyanhydrides by reaction of the corresponding amino acid with phosgene, diphosgene and/or triphosgene in a solvent medium, characterized in that the reaction is a least partially carried out in the presence of an unsaturated organic compound which has one or more ethylenic double bonds. The N-carboxyanhydrides are thus obtained with better yields and an improved purity.