166318-75-8

Basic information

• Product Name: 1-Hydroxy-1-(4-methylphenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester
• Synonyms: 1-Hydroxy-1-(4-methylphenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester
• CAS NO: 166318-75-8
• Molecular Weight: 700.605
• Mol File: 166318-75-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Hydroxy-1-(4-methylphenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxy-1-(4-methylphenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester(166318-75-8)
• EPA Substance Registry System: 1-Hydroxy-1-(4-methylphenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester(166318-75-8)

Safety Data

• Hazardous Substances Data: 166318-75-8(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 151029-28-6 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl) H-phosphonate diester 

Downstream Products

• 30516-87-1 3'-azido-2',3'-deoxythymidine 
• 124930-59-2 3'-azido-3'-deoxythymidin-5'-yl H-phosphonate monoester 

Relevant articles and documents

Homo dinucleoside-α-hydroxyphosphonate diesters as prodrugs of the antiviral nucleoside analogues 2',3'-dideoxythymidine and 3'-azido-2',3'- dideoxythymidine

The synthesis of a new prodrug system for antiviral nucleosides AZT (1) and ddT (2) based on α-hydroxyhenzylphosphonates 3 is described. 3 hydrolyze via different mechanisms yielding the H-phosphonate monoesters 4 or nucleoside monophosphates 5, respectively, 3 were more lipophilic than 1, 2 and showed marked activity against HIV-1/2.