166411-42-3

Basic information

• Product Name: 1,2-O-isopropylidene-3-deoxy-3-(p-toluenesulfonylhydrazino)-5-O-benzoyl-α-L-ribofuranose
• Synonyms: 1,2-O-isopropylidene-3-deoxy-3-(p-toluenesulfonylhydrazino)-5-O-benzoyl-α-L-ribofuranose
• CAS NO: 166411-42-3
• Molecular Weight: 462.524
• Mol File: 166411-42-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,2-O-isopropylidene-3-deoxy-3-(p-toluenesulfonylhydrazino)-5-O-benzoyl-α-L-ribofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-O-isopropylidene-3-deoxy-3-(p-toluenesulfonylhydrazino)-5-O-benzoyl-α-L-ribofuranose(166411-42-3)
• EPA Substance Registry System: 1,2-O-isopropylidene-3-deoxy-3-(p-toluenesulfonylhydrazino)-5-O-benzoyl-α-L-ribofuranose(166411-42-3)

Safety Data

• Hazardous Substances Data: 166411-42-3(Hazardous Substances Data)

Upstream product

• 166411-40-1 5-O-benzoyl-1,2-O-isopropylidene-α-L-erythro-pentofuranose-3-ulose 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-88-4 benzoyl chloride 
• 41546-31-0 L-xylose 
• 166411-41-2 5-O-benzoyl-1,2-O-isopropylidene-p-toluenesulfonylhydrazone-α-L-erythro-pentofurano-3-ulose 

Downstream Products

• 255818-76-9 2-isobutyrylamino-6-chloro-9-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)purine 
• 255818-77-0 2-isobutyrylamino-6-chloro-9-(5-O-benzoyl-2,3-dideoxy-2-fluoro-α-L-threo-pentofuranosyl)purine 
• 255818-50-9 5-iodo-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)uracil 
• 255818-51-0 5-iodo-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-α-L-threo-pentofuranosyl)uracil 
• 255818-56-5 5-iodo-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)cytosine 
• 186648-63-5 5-fluoro-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)uracil 
• 255818-47-4 5-fluoro-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-α-L-threo-pentofuranosyl)uracil 
• 255818-48-5 5-bromo-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)uracil 
• 255818-49-6 5-bromo-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-α-L-threo-pentofuranosyl)uracil 
• 255818-54-3 5-fluoro-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)cytosine 
• 255818-58-7 5-chloro-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)cytosine 
• 255818-55-4 5-bromo-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)cytosine 
• 255818-59-8 1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)thymine 
• 255818-57-6 5-methyl-1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)cytosine 

Relevant articles and documents

Monocyclic L-nucleosides with type 1 cytokine-inducing activity

A series of 1,2,4-triazole L-nucleosides were synthesized and evaluated for their ability to stimulate type i cytokine production by activated human T cells in direct comparison to the known active agent ribavirin. Among the compounds prepared, 1-β-L-ribofuranosyl-1,2,4-triazole-3-carboxamide (5, ICN 17261) was found to be the most uniformly potent compound. Conversion of the 3-carboxamide group of 5 to a carboxamidine functionality resulted in 1-β-L- ribofuranosyl-1,2,4-triazole-3-carboxamidine hydrochloride (10), which induced cytokine levels comparable to 5 for two of the three type 1 cytokines examined. Modification of the carbohydrate moiety of 5 provided compounds of reduced activity. Significantly, ICN 17261 offers interesting immunomodulatory potential for the treatment of diseases where type I cytokines play an important role.