1666-02-0Relevant articles and documents
Inhibition of Urease, a Ni-Enzyme: The Reactivity of a Key Thiol With Mono- and Di-Substituted Catechols Elucidated by Kinetic, Structural, and Theoretical Studies
Mazzei, Luca,Contaldo, Umberto,Musiani, Francesco,Cianci, Michele,Bagnolini, Greta,Roberti, Marinella,Ciurli, Stefano
, p. 6029 - 6035 (2021)
The inhibition of urease from Sporosarcina pasteurii (SPU) and Canavalia ensiformis (jack bean, JBU) by a class of six aromatic poly-hydroxylated molecules, namely mono- and dimethyl-substituted catechols, was investigated on the basis of the inhibitory efficiency of the catechol scaffold. The aim was to probe the key step of a mechanism proposed for the inhibition of SPU by catechol, namely the sulfanyl radical attack on the aromatic ring, as well as to obtain critical information on the effect of substituents of the catechol aromatic ring on the inhibition efficacy of its derivatives. The crystal structures of all six SPU-inhibitors complexes, determined at high resolution, as well as kinetic data obtained on JBU and theoretical studies of the reaction mechanism using quantum mechanical calculations, revealed the occurrence of an irreversible inactivation of urease by means of a radical-based autocatalytic multistep mechanism, and indicate that, among all tested catechols, the mono-substituted 3-methyl-catechol is the most efficient inhibitor for urease.
Two Colour Photoflow Chemistry for Macromolecular Design
Barner-Kowollik, Christopher,Blinco, James P.,De Bruycker, Kevin,Van De Walle, Matthias
, p. 14143 - 14147 (2020)
We report a photochemical flow setup that exploits λ-orthogonal reactions using two different colours of light (λ1=350 nm and λ2=410 nm) in sequential on-line irradiation steps. Critically, both photochemically reactive units (a visi
Mixture, polymer, optical film, optically anisotropic body, polarizing sheet, display device, antireflective film, and manufacturing method for mixture
-
Paragraph 0449-0455, (2019/02/28)
A purpose of the present invention is to provide a means by which a polymer can be efficiently manufactured, said polymer being able to be used in the production of an optical film or similar with good reverse wavelength dispersion. In a mixture according to the present invention, the included amount of a polymerizable compound (I) indicated by formula (I) is greater than 0.2 times the included amount of a polymerizable compound (II) indicated by formula (II). (In the formulas, Ar1 and Ar2 are prescribed ring groups; A1-A4 and B1-B4 are cyclic aliphatic groups or aromatic groups and can have a substituent group; Z1-Z4, Y1-Y4, and L1-L4 are prescribed groups such as -O-, -C(=O)-O-, or -O-C(=O)-; R1-R6 are hydrogen atoms, methyl groups, or chlorine atoms; one of e and f is an integer from 1 to 3 and the other is an integer from 0 to 3; c, d, i, and j are integers from 1 to 20; and a, b, g, and h are 0 or 1).