1669-43-8

Basic information

• Product Name: 5-methyl-hex-3c-en-2-one
• Synonyms: 5-methyl-hex-3c-en-2-one
• CAS NO: 1669-43-8
• Molecular Weight: 112.172
• Mol File: 1669-43-8.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 5-methyl-hex-3c-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-hex-3c-en-2-one(1669-43-8)
• EPA Substance Registry System: 5-methyl-hex-3c-en-2-one(1669-43-8)

Safety Data

• Hazardous Substances Data: 1669-43-8(Hazardous Substances Data)

Upstream product

• 65651-63-0 4-hydroxy-5-methyl-hexan-2-one 
• 59697-04-0 5-methyl-4-(toluene-4-sulfonyloxy)-hexan-2-one 
• 869096-24-2 9-tolylsulfonyl-4,9-dihydro-3H-β-carboline 
• 623-15-4 (E)-4-(furan-2-yl)but-3-en-2-one 
• 995-05-1 Acetonyl-diethyl-phosphinoxid 
• 78-84-2 isobutyraldehyde 
• 67-56-1 methanol 
• 67-64-1 acetone 
• 35794-11-7 3,5-dimethylpiperidine 
• 623-58-5 sodium aceto-acetate 
• 876-27-7 4-chlorophenyl acetate 
• 146513-95-3 (rac,E)-5-methylhex-3-en-2-ol 
• 7553-56-2 iodine 
• 75-36-5 acetyl chloride 

Downstream Products

• 219307-86-5 cis-4-Hydroxy-6-isopropyl-4-methyl-2-(4-methylphenyl)-5,6-dihydro-4H-1,3-selenazine 
• 219307-86-5 trans-4-Hydroxy-6-isopropyl-4-methyl-2-(4-methylphenyl)-5,6-dihydro-4H-1,3-selenazine 
• 873430-03-6 5-tert-butyldiphenylsilylmethyl-4-isopropylhex-5-en-2-one 
• 13706-86-0 5-methyl-2,3-hexanedione 
• 1421697-79-1 (4R,12bS)-4-(2-methylprop-1-enyl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one 
• 435269-66-2 (S)-5-methyl-4-phenylhexan-2-one 
• 162239-77-2 (R)-5-methyl-4-phenyl-hexan-2-one 
• 120609-18-9 (+/-)-5-methyl-4-phenylhexan-2-one 

Relevant articles and documents

Proline-catalyzed ketone-aldehyde aldol reactions are accelerated by water

Proline-catalyzed aldol reactions between acetone or 4-thianone and different aldehydes are accelerated by addition of 1-10 equivalents of water to the reaction medium, allowing stoichiometric aldol reactions to proceed at acceptable rates.

Catalytic Asymmetric Conjugate Addition of Indolizines to α,β-Unsaturated Ketones

A catalytic enantioselective conjugate addition of indolizines to enones is described. The chiral phosphoric acid (S)-TRIP activates α,β-unsaturated ketones, thereby promoting an enantioface-differentiating attack by indolizines. Using this reaction, several alkylated indolizines were synthesized in good yields and with enantiomeric ratios of up to 98:2.

Design, synthesis and biological evaluation of novel C3-functionalized oxindoles as potential Pim-1 kinase inhibitors

A novel series of C3-functionalized oxindoles, 3-(2-oxo-4-phenylbut-3-en-1-ylidene)indolin-2-ones, were designed, synthesized and investigated for inhibition of cell proliferation against different types of human cancer cell lines, including SW620, HeLa and A549. This biological study showed that these compounds containing the scaffolds of indole and aromatic α,β-unsaturated ketone had moderate to significant antitumor activities. Further study suggested that compound 4b, as one of this kind of structure derivative, showed broad-spectrum antitumor activities against MCF-7, PC-3, SKOV-3, U87, SMMC-7721, SY5Y and A875 cancer cell lines. Besides, the results of the inhibition of Pim kinases indicated that compound 4b showed selective and efficient anti-Pim-1 kinase activity (IC50 = 5 μM). Docking simulation, flow cytometry (FCM), and Hoechst 33342 staining assay suggested that the most active compound 4b induced cell death through apoptosis via binding to the active ATP pocket of Pim-1. Moreover, it showed that compound 4b had strong inhibition of tubulin polymerization which may be caused by inhibiting Pim-1. This journal is