16698-35-4Relevant articles and documents
Kinetics of the reaction by which natural vitamin E is regenerated by vitamin C
Nagaoka, Shin-ichi,Kakiuchi, Takuhiro,Ohara, Keishi,Mukai, Kazuo
, p. 26 - 32 (2007)
The rate constant and activation energy of the regeneration reaction of natural vitamin E by vitamin C were determined with a double-mixing stopped-flow spectrophotometer. The formation of vitamin C radical was observed in the absorption spectrum. The kinetic effect of methyl substitution on the aromatic ring of vitamin E radical indicates that partial charge-transfer plays a role in the reaction. Since a substantial deuterium kinetic isotope effect was not found, the tunneling effect may not play an important role under the present experimental conditions.
Process of separating chiral isomers of chroman compounds and their derivatives and precursors
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Page/Page column 15, (2012/12/13)
The present invention relates to a process of separating chiral isomers of chroman compounds, particularly tocopherols and tocotrienols as well as the esters and intermediates thereof. It has been found that this process allows a separation of the desired isomer with a higher yield and enables the use of the non-desired isomers in a very efficient way. Said process is particularly useful when implemented in an industrial process. Furthermore, it has been found that this process allows using isomer mixtures as they result from traditional industrial synthesis.
Tocopherols by hydride reduction of dialkylamino derivatives
Netscher, Thomas,Mazzini, Francesco,Jestin, Roselyne
, p. 1176 - 1183 (2008/02/08)
Aminomethylation with Mannich reagents derived from secondary amines and paraformaldehyde under improved conditions has been used to convert non-α-tocopherol homologues into α-tocopherol, the biologically most important vitamin E compound. Mono- and bis(aminomethylated) β-, γ-and δ-tocopherol were then subsequently transformed into the corresponding tocopherols (α- and β-tocopherol) by reductive deamination. As an alternative to classical catalytic hydrogenation in the last step, efficient laboratory protocols using complex hydrides have been derived and applied to the preparation of labelled vitamin E compounds. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
