167027-28-3 Usage
Methyl ester derivative
1H-Indole-2-carboxylic acid, 7-nitro-, methyl ester is a derivative of 7-nitroindole-2-carboxylic acid in which a methyl group (CH3) has been added to the carboxylic acid group (-COOH).
Used in organic synthesis and pharmaceutical research
This compound is commonly used as a building block or precursor in the synthesis of more complex organic molecules, including pharmaceutical drugs.
Potential application in drug development
1H-Indole-2-carboxylic acid, 7-nitro-, methyl ester has potential applications in the development of new drugs, particularly in the fields of neuroscience and cancer research.
Nitro group
The presence of a nitro group (-NO2) on the indole ring makes this compound a useful precursor for the synthesis of nitrogen-containing compounds with biological and pharmacological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 167027-28-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,0,2 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 167027-28:
(8*1)+(7*6)+(6*7)+(5*0)+(4*2)+(3*7)+(2*2)+(1*8)=133
133 % 10 = 3
So 167027-28-3 is a valid CAS Registry Number.
167027-28-3Relevant articles and documents
Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile
Jiang, Hai-Xia,Zhuang, Dao-Min,Huang, Ying,Cao, Xing-Xin,Yao, Jian-Hua,Li, Jing-Yun,Wang, Jian-Yong,Zhang, Chen,Jiang, Biao
, p. 3446 - 3458 (2014)
A novel series of trifluoromethyl indole derivatives have been designed, synthesized and evaluated for anti-HIV-1 activities in MT-2 cells. The hydrophobic constant, acute toxicity, carcinogenicity and mutagenicity were predicted. Trifluoromethyl indoles 10i and 10k showed extremely promising activities against WT HIV-1 with IC50 values at the low nanomolar level, similar to efavirenz, better than nevirapine, and also possessed higher potency towards the drug-resistant mutant strain Y181C than nevirapine. Preliminary SAR and docking studies of detailed binding mode provided some insights for discovery of more potent NNRTIs. the Partner Organisations 2014.
