1671-82-5

Basic information

• Product Name: 1-methyl-2-nitroimidazole
• Synonyms: 1-methyl-2-nitroimidazole;1-Methyl-2-nitro-1H-imidazole;1H-IMidazole,1-Methyl-2-nitro-;2-Nitro-1-methylimidazole
• CAS NO: 1671-82-5
• Molecular Formula: C₄H₅N₃O₂
• Molecular Weight: 127.1
• Mol File: 1671-82-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 100-102 °C
• Boiling Point: 235.85°C (rough estimate)
• Flash Point: 140.6°C
• Appearance: /
• Density: 1.4748 (rough estimate)
• Vapor Pressure: 0.000662mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Storage Temp.: 2-8°C
• PKA: 1.10±0.25(Predicted)
• CAS DataBase Reference: 1-methyl-2-nitroimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-nitroimidazole(1671-82-5)
• EPA Substance Registry System: 1-methyl-2-nitroimidazole(1671-82-5)

Safety Data

• Hazardous Substances Data: 1671-82-5(Hazardous Substances Data)

Usage

General Description

1-methyl-2-nitroimidazole is a chemical compound with the molecular formula C4H5N3O2. It is a nitro derivative of imidazole and is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. 1-methyl-2-nitroimidazole is a pale yellow crystalline solid that is insoluble in water but soluble in organic solvents. It is also known to have antimicrobial and antifungal properties, making it useful in the development of new pharmaceutical products. Additionally, 1-methyl-2-nitroimidazole is used as a raw material for the production of various dyes and pigments. Its functional groups, including the nitro and imidazole moieties, make it a versatile building block for the synthesis of diverse organic compounds.

InChI:InChI=1/C4H5N3O2/c1-6-3-2-5-4(6)7(8)9/h2-3H,1H3

Upstream product

• 527-73-1 2-nitro-1H-imidazole 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 74-88-4 methyl iodide 
• 616-47-7 1-methyl-1H-imidazole 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 121816-79-3 4-bromo-1-methyl-2-nitroimidazole 
• 151597-78-3 5-bromo-1-methyl-2-nitroimidazole 
• 6646-51-1 1-methyl-2-aminoimidazole 
• 1361182-32-2 1-methyl-2-nitroimidazolium picrate 
• 113342-91-9 4,5-dibromo-1-methyl-2-nitroimidazole 

Related news

Molecular and Cellular PharmacologyOxidative Stress and 1-methyl-2-nitroimidazole (cas 1671-82-5) Cytotoxicity09/24/2019

The 2-nitroimidazoles have been used clinically to radiosensitize resistant hypoxic cells, but a dose-limiting peripheral neuropathy has restricted their therapeutic effectiveness. A model compound, 1-methyl-2-nitroimidazole (INO2), was used to investigate the possible role of oxidative stress i...detailed

Relevant articles and documents

THE SYNTHESIS OF AZOMYCIN.

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COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS

The invention relates to a compound of Formula I, pharmaceutical compositions comprising a compound of Formula I, and pharmaceutically acceptable slats thereof, pharmaceutical compositions comprising such compounds and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I to a subject in need thereof.

INHIBITORS OF BRUTON'S TYROSINE KINASE

Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Melt-cast explosive material

1-Methyl-2,4,5-Trinitroimidazole is synthesized starting from 4-nitroimidazole using stepwise nitration method and further methylation using Dimethylsulphate. It is relatively insensitive to impact and its thermal stability is excellent. The calculated detonation properties indicate that its performance is about 30% better than TATB. It can be prepared easily, with reasonable yield, starting from commercially available Imidazole. Results from impact sensitivity, friction sensitivity, time-to-explosion temperature and vacuum stability tests indicate that it is less sensitive than both RDX and HMX. The good oxygen balance and measured heat of formation data of this material indicate that its propellant performance should be good.