1672-76-0 Usage
Description
Chlorpromazine N-oxide, also known as chlorpromazine oxide, is an organochlorine compound derived from chlorpromazine. It is formed by the conversion of the acyclic tertiary amino group in chlorpromazine into the corresponding N-oxide. This modification enhances the compound's properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
Chlorpromazine N-oxide is used as a pharmaceutical agent for its potential therapeutic effects. The conversion of the amino group to an N-oxide may improve the compound's stability, solubility, and bioavailability, making it a more effective drug candidate for treating various medical conditions.
Used in Chemical Research:
Chlorpromazine N-oxide serves as a valuable compound in chemical research, particularly in the study of organochlorine compounds and their properties. It can be used to investigate the effects of N-oxide formation on the chemical behavior and reactivity of chlorpromazine and other related compounds.
Used in Drug Delivery Systems:
Similar to gallotannin, chlorpromazine N-oxide can be incorporated into drug delivery systems to enhance its therapeutic potential. By utilizing various carriers such as organic and metallic nanoparticles, the delivery, bioavailability, and overall efficacy of chlorpromazine N-oxide can be improved, leading to better treatment outcomes for patients.
Metabolic pathway
When female rats are administered chlorpromazine N-
oxide orally, the metabolites identified in both urine
and feces are chlorpromazine, 7-
hydroxychlorpromazine, chlorpromazine sulfoxide, N-
desmethylchlorpromazine and N-
desmethylchlorpromazine sulfoxide. Chlorpromazine
N-oxide and any metabolite that retains the intact N-
oxide function, such as chlorpromazine N,S-dioxide,
cannot be identified in any of the extracts.
Check Digit Verification of cas no
The CAS Registry Mumber 1672-76-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,7 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1672-76:
(6*1)+(5*6)+(4*7)+(3*2)+(2*7)+(1*6)=90
90 % 10 = 0
So 1672-76-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H19ClN2OS/c1-20(2,21)11-5-10-19-14-6-3-4-7-16(14)22-17-9-8-13(18)12-15(17)19/h3-4,6-9,12H,5,10-11H2,1-2H3
1672-76-0Relevant articles and documents
Bacterial Biosynthetic P450 Enzyme PikCD50N: A Potential Biocatalyst for the Preparation of Human Drug Metabolites
Cheng, Fangyuan,Du, Lei,Durairaj, Pradeepraj,Guo, Jiawei,Li, Fengwei,Li, Shengying,Liu, Xiaohui,Long, Xiangtian,Ma, Li,Tang, Dandan,Zhang, Gang,Zhang, Wei,Zhang, Xingwang
, p. 14563 - 14571 (2021/11/12)
Human drug metabolites (HDMs) are important chemicals widely used in drug-related studies. However, acquiring these enzyme-derived and regio-/stereo-selectively modified compounds through chemical approaches is complicated. PikC is a biosynthetic P450 enz
Synthesis of the N-oxides of phenothiazine antipsychotic agents
Jaworski,Sardessai,Aravagiri,Lin,Shi,Hawes,Hubbard,McKay,Midha
, p. 330 - 333 (2007/10/02)
Chlorpromazine N-oxide, fluphenazine N(4')-oxide, prochlorperazine N(4')- oxide, sulforidazine N-oxide, and trifluoperazine N(4')-oxide were synthesized by oxidation of the designated nitrogen atom in the N-10 side chain of the respective parent drug with 3-chloroperoxybenzoic acid. In the case of trifluoperazine, a stepwise increase in the amount of oxidant yielded the N(1'),N(4')-dioxide and N(1'),N(4'),S-trioxide. The N',S-dioxides of chlorpromazine and sulforidazine were obtained by hydrogen peroxide oxidation of the appropriate parent drug.
