16721-43-0

Basic information

• Product Name: Phosphonium, triphenylpropyl-, chloride
• CAS NO: 16721-43-0
• Molecular Formula: C21H22P.Cl
• Molecular Weight: 340.832
• Mol File: 16721-43-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phosphonium, triphenylpropyl-, chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonium, triphenylpropyl-, chloride(16721-43-0)
• EPA Substance Registry System: Phosphonium, triphenylpropyl-, chloride(16721-43-0)

Safety Data

• Hazardous Substances Data: 16721-43-0(Hazardous Substances Data)

Upstream product

• 791-28-6 Triphenylphosphine oxide 
• 2234-82-4 1-propylmagnesium chloride 
• 19171-57-4 dichlorotriphenyl-λ⁴-phosphane 
• 16666-78-7 propylidenetriphenylphosphorane 
• 1071-38-1 N,N,N',N'-Tetramethylformamidinium chloride 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 83299-48-3 {(C₆H₅)3PC₃H₇}⁽¹⁺⁾*{FeCl₄}^(1-)={(C₆H₅)3PC₃H₇}{FeCl₄} 
• 126664-43-5 (1R,2S,3R,2''Z)-3-(Benzyloxy)-1-(2-hydroxyethyl)-2-(2-pentenyl)cyclopentan 

Relevant articles and documents

Long sought synthesis of quaternary phosphonium salts from phosphine oxides: Inverse reactivity approach

Quaternary phosphonium salts (QPS), a key class of organophosphorus compounds, have previously only been available by routes involving nucleophilic phosphorus. We report the realisation of the opposite approach to QPS utilising phosphine oxides as the electrophilic partner and Grignard reagents as nucleophiles. The process is enabled through the crucial intermediacy of the derived halophosphonium salts. The route does not suffer from the slow kinetics and limited availability of many parent phosphines and a broad range of QPS were prepared in excellent yields.

Reactions with Phosphine Alkylenes, XLV. Reactions of Alkylidenetriphenylphosphoranes with Tetramethylformamidinium Chloride. Synthesis of triphenylphosphonium Chloride and (Formylalkylidene)triphenylphosphoranes

Phosphonium ylides 1 react with tetramethylformamidinium chloride (2) to form enamine phosphonium chlorides 8 and the formic orthoamide 7.The salts 8 show temperature depending 1H NMR spectra with respect to the protons of the dimethylamino group (hindered rotation around the C - N(CH3)2 bond).Treatment of 8 with acids and subsequently with bases gives rise to the formation of the formyl ylides 19. 8a is deprotonated with sodium amide to give the phosphaallene ylide 20, which reacts with water to yield the phosphane oxide 21, and with methyl iodide stereospecifically to form 8b.